Decreased serum SLC7A11 and GPX4 levels may reflect disease severity of acute ischaemic stroke.

Objective: This study aimed to examine the levels of solute carrier family seven number 11 (SLC7A11) and glutathione peroxidase 4 (GPX4) in the serum of patients with acute ischaemic stroke (AIS) and their relationship with disease severity.

Methods: A total of 148 patients with AIS together with 148 healthy controls (HCs) were enrolled. The expression levels of SLC7A11 and GPX4 in serum were detected immediately as early as possible.

"Hesitating and Puzzling": The Experiences and Decision Process of Acute Ischemic Stroke Patients with Prehospital Delay after the Onset of Symptoms.

Despite campaigns to increase public awareness of stroke symptoms by advocating FAST (Face-Arms-Speech-Time), some stroke patients still show delays in the recognition of and response to stroke symptoms and miss the golden first 4.5 h to receive rt-PA (recombinant tissue plasminogen activator) treatment. The aim of this study was to explore how acute ischemic stroke patients with prehospital delay seek help and undergo the decision process before arriving at the hospital.

Lack of association between single nucleotide polymorphisms in TCF7L2 and T2DM in the Chinese Yao population: A case-control study.

Single-nucleotide polymorphisms (SNPs) in the transcription factor 7-like 2 (TCF7L2) gene have been identified to be associated with the susceptibility to type 2 diabetes mellitus (T2DM) in various populations worldwide, but the results in Chinese are conflicting, and no data are available about the Liannan Yao population. Therefore, this study aimed to investigate the association of the TCF7L2 gene polymorphisms (rs12255372, rs7903146, rs7901695, rs11196205, and rs7895340) with T2DM in the Yao population living in the rural areas in the Liannan Yao Autonomous County.This was a case-control study of 28 subjects with T2DM or prediabetes and 52 non-T2DM controls, all from the Chinese Yao population and recruited between January 2019 and June 2020.

[Choosing, Challenging, Stabilizing, and Fulfilling: The Experiences of Palliative Care at Home as Perceived by Family Caregivers].

Background: Although the Taiwan government has subsidized the provision of palliative care at home since 2000, the utilization rate of this service has been low.

Purpose: The purpose of this research is to explore the experiences of palliative care at home as perceived by family caregivers.

Methods: This qualitative study used semi-structured interviews to collect the data.

The involvement of Kras gene 3'-UTR polymorphisms in risk of cancer and influence on patient response to anti-EGFR therapy in metastatic colorectal cancer: a meta-analysis.

Background: Genetic variation of the Kras oncogene is a candidate factor for increasing susceptibility to carcinoma and modulating response of metastatic colorectal cancer (mCRC) patients treated with anti-epidermal growth factor receptor monoclonal antibody (anti-EGFR). However, results from an increasing number of studies concerning the association of Kras gene rs712 and rs61764370 polymorphisms with risk of cancer and treatment of mCRC using anti-EGFR remain equivocal.

Methods: Risk associations were evaluated in 1,661 cases and 2,139 controls from six studies concerning rs712 and 14,796 cases and 14,985 controls from 29 studies concerning rs61764370.

Glucagon-like peptide-1 (GLP-1) protects vascular endothelial cells against advanced glycation end products (AGEs)-induced apoptosis.

Background: The peptide glucagon-like peptide-1 (GLP-1) is a hormone secreted by intestinal L cells in response to food intake. GLP-1 has been proposed as the basis of emerging therapy for patients with type 2 diabetes. However, the effects of GLP-1 on vascular injury in diabetes have not been identified.

[Facing, accepting, growing and expecting: the practical experience of nursing students during their first clinical practice].

Background: Clinical practice experiences, while important, can be highly stressful for nursing students and have a deep effect on their subsequent professional development.

Purpose: This study explored nursing student experiences during their first clinical practice.

Methods: The study used exploratory and descriptive research methodologies, and researchers selected a phenomenological approach to analysis.

Sailing against the tide: Taiwanese women's journey from pregnancy loss to motherhood.

Purpose: To understand the experiences of Asian women in Taiwan who are adjusting to motherhood following previous pregnancy loss.

Study Design And Methods: Phenomenology was used as the study design, and interviews were used to collect data in a medical center in Northern Taiwan with six women who had given birth to a healthy baby after previous pregnancy loss. Following ethical approval, interviews were audio-recorded, transcribed, and analyzed to develop data themes.

[An experience of providing emergency care on the basis of Watson's theory to a toddler suffering from minor burns].

This article explores the application of Watson's Caring Theory to a child suffering from minor burns injury and his mother. After the nursing process, their physical and social-psychological needs were met. A trauma accident always affects the child and the caregiver, especially the mother.