Publications by authors named "Hui-Li Liu"

Article Synopsis
  • Researchers created new membranes using polyether ether ketone-based polymers with ion-cross-linkable quaternary ammonium and acidic side chains to selectively allow certain cations to pass through.
  • They explored three types of acidic groups (sulfonic acid, carboxylic acid, and phenolic hydroxyl) that form ionic links in the membranes, influencing their structure and performance.
  • The study found that while cation flux improved with increased acidity, the selectivity varied, with carboxyl group membranes showing the best selectivity for lithium over magnesium, outperforming existing commercial membranes.
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Objectives: To investigate the role of normal weight central obesity (NWCO) in the prognosis of sudden sensorineural hearing loss (SSNHL).

Methods: We retrospectively investigated 807 cases of SSNHL from January of 2008 to August of 2019 from the Department of Otorhinolaryngology at Kaohsiung Medical University Hospital in southern Taiwan. We analyzed the association between overweight and obesity, NWCO, and the prognosis of SSNHL.

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Objective: To investigate the incidence and potential influence factors that contribute to chronic post-surgical pain (CPSP) in elderly patients with urinary tract tumors who underwent laparoscopic procedures.

Methods: A retrospective study was conducted to collect the clinical data of 182 elderly patients with urinary tract tumors who were ≥65 years and underwent laparoscopic surgery from October 2021 to March 2022 in Peking University Third Hospital. The patients'demographic information, medical history and the severity of postoperative pain were collected.

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Article Synopsis
  • The study examined the prevalence of vaginal flora and antibiotic resistance in bacterial vaginitis among 3099 girls aged 0-10 who visited a hospital in Beijing between 2020-2021.
  • Out of these, 399 girls had positive bacterial cultures, with a total of 19 bacterial types identified, indicating higher infection rates in school-age girls and a seasonal trend, with more cases in summer.
  • Notably, high resistance rates (70-100%) to antibiotics like clindamycin and erythromycin were found, though some resistance improved post-COVID-19, emphasizing the need for better understanding and treatment strategies for vaginitis in young girls.
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Phthalates are non-persistent chemicals used in products of daily necessities. The evidence on the relationship of prenatal phthalates exposure and preterm birth remain uncertain and dimed. We Searched Cochrane, EMBASE, PubMed and Qvid Medline and selected studies according to a priori defined inclusion criteria.

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  • A new and efficient nitrogen insertion reaction was developed for creating 2,3-disubstituted quinazolinone derivatives without using transition metals.
  • The process effectively utilized various functionalized 3-indolinone-2-carboxylates and nitroso compounds, yielding products in high amounts (69-98%).
  • The method was scalable, successfully producing a gram-scale reaction, and demonstrated the ability to synthesize an afloqualone analogue under mild conditions.
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Objective: To investigate the effects of down-regulating of c-Met expression to the proliferation, invasiveness and apoptosis of human multiple myeloma RPMI 8226 cells.

Methods: According to transfection the RPMI8226 cells were dividide into RPMI 8226 (untreated RPMI 8226), RPMI 8226 /shRNA-Met and RPMI8226/shRNA-control group, respectively. Protein expression level of c-Met was detected by Western blot so as to evaluate transfection condition; the proliferation of the cells was detected by MTT; apoptosis and cycle of the cells were detected by flow cytometry; effect of c-Met/shRNA on RPMI 8226 cell adhesion was detected by RPMI 8226 cell adherence to ECM (Fn and Matrigel) and ECV304 cells.

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The Arabidopsis FERONIA (FER) receptor kinase is a key hub of cell signaling networks mediating various hormone, stress, and immune responses. Previous studies have shown that FER functions correlate with auxin responses, but the underlying molecular mechanism is unknown. Here, we demonstrate that the primary root of the fer-4 mutant displays increased lateral root branching and a delayed gravitropic response, which are associated with polar auxin transport (PAT).

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Objective: To establish bortezomib (BOR)-resistant human multiple myeloma U266 cell line U266/BOR and to detect its biological characteristics.

Methods: U266 cells were constantly exposed at low dose and progressively increasing dose of BOR to establish U266/BOR, the cell morphology was observed by inverted microscopy, IC and resistant index were determined by MTT assay, cell growth curve was drawed and the doubling time was calculated; cell cycle distribution were analyzed by flow cytometry, and RT-PCR was used to detect the mRNA expression of resistance-related genes.

Results: The MM U266/BOR cell line was successfully constructed and its resistance index was up to 19.

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The dried stems of Schisandra henryi var. henryi were extracted with 95% ethanol and the extracts were further subjected to partition, affording the ethyl acetate extracts(EtOAc Extrs.).

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The organocatalytic asymmetric allylic etherification reaction of Morita-Baylis-Hillman carbonates and silanols was reported for the first time. With modified cinchona alkaloid (DHQD)PYR as the catalyst, a series of aromatic, heterocyclic, or aliphatic Morita-Baylis-Hillman carbonates (25 examples) worked well with triphenylsilanol, affording the corresponding products in moderate to good yields (up to 98%), high regioselectivities (>20:1), and good enantioselectivities (up to 92%). When dimethylphenylsilanol was used as the nucleophile, the product was obtained in 60% yield and 87% ee.

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Background: Nicotine hinders the regenerative potentials of human periodontal ligament-derived stem cells (PDLSCs) and delays the healing process of periodontal diseases, but the underlying mechanism remains unclear. miR-1305 upregulation and its potential target RUNX2 downregulation exist in the PDLSCs exposed to nicotine. In this study, we aimed to investigate whether nicotine inhibits PDLSC proliferation, migration, and osteogenic differentiation by increasing miR-1305 level and decreasing RUNX2 level.

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Background: Placenta accreta is a rare obstetric condition but can lead to life-threatening complications that was mainly diagnosed in the third trimester. We present a case of acute trophoblastic pulmonary embolism (PE) during conservative treatment of placenta accreta.

Case Presentation: A 24-year-old patient who delivered vaginally at 40(+4) weeks gestation.

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Trichomonas vaginalis is a flagellated protozoan parasite that infects the human urogenital tract, causing the most common non-viral, sexually transmitted disease worldwide. In this study, genetic variants of T. vaginalis were identified in Henan Province, China.

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Objective: To evaluate the combined effect of premedication of parecoxib sodium and local infiltration of ropivocaine on postoperative shoulder pain and incisional pain in patients undergoing diagnostic hysteroscopy and laparoscopy.

Methods: In the study, 60 patients undergoing elective diagnostic hysteroscopy and laparoscopy were randomly allocated to two groups (each with 30 patients). The patients in group 1 were premedicated with 40 mg parecoxib sodium (diluted with 2 mL normal saline), and 0.

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This study was aimed to investigate the antitumor effect of pumpkin protein (cucurmosin, CUS) on subcutaneous transplant tumor in chronic myeloid leukemia K562 cell-NOD/SCID mice and leukemia model. The subcutaneous transplant tumor in K562-NOD/SCID mice and leukemia model were established; using two models, the antitumor activity of CUS in mice was evaluated. The results indicated that the inhibitory rate of 0.

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Previously our study has demonstrated that long-term treadmill exercise improved cognitive deficit in APP/PS1 transgenic mice of Alzheimer's disease (AD) paralleled by enhanced long-term potentiation (LTP). The present study was undertaken to further investigate whether the treadmill running could inhibit the progression of Alzheimer's disease (AD)-like neuropathology in hippocampus of the APP/PS1 mouse models of AD, and to define a potential molecular mechanism underlying the exercise-induced reduction in AD-like neuropathology. Five months of treadmill exercise resulted in a robust reduction in β-amyloid (Aβ) deposition and tau phosphorylation in the hippocampus of APP/PS1 mice.

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Article Synopsis
  • Aluminum, a neurotoxin linked to Alzheimer's disease (AD), was shown to cause brain changes similar to AD, including tau hyperphosphorylation in mice.
  • Ginsenoside Rb1, an active component in ginseng, demonstrated neuroprotective effects by improving cognitive function and decreasing tau hyperphosphorylation in mice previously exposed to aluminum.
  • The study suggests that Rb1's protective mechanism involves regulation of specific proteins (p-GSK3 and PP2A), positioning it as a potential preventive treatment for Alzheimer's and related neurodegenerative diseases.
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Objective: To study the application of the regional critical neonatal emergency transport system (NETS) to provide evidence for the optimization of NETS in Beijing.

Methods: All the transported neonates in four hospitals in Haidian District, Beijing, between January 2009 and September 2010 were enrolled. The relevant clinical information of two referral hospitals was analyzed.

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Objective: The purpose of this study was to establish the streptozotocin (STZ)-induced diabetic model with rats and investigate the antinociceptive effect of combination of Tramadol (TR) and Acetaminophen (NAPA) on the animal model for the first time.

Methods: Diabetic model was induced by a single injection of STZ (60 mg/kg, intraperitoneal). Nociceptive thresholds were measured by means of electronic von Frey test, hot-plate test, and tail-flick test.

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Article Synopsis
  • Alzheimer's disease (AD) leads to gradual deterioration of learning and memory, and while exercise has shown cognitive benefits, its specific cellular and molecular interactions in AD are not well understood.
  • This study focused on the impact of treadmill exercise on learning and memory in APP/PS1 transgenic mice, a model for Alzheimer's, and found that exercise improved cognitive performance and long-term potentiation (LTP) in these mice, similar to wild-type mice.
  • The results highlight that while exercise enhanced learning and memory through improved LTP, the role of brain-derived neurotrophic factor (BDNF) as a synaptic regulator was significant in wild-type but not in APP/PS1 mice, indicating different underlying mechanisms in Alzheimer’s pathology.
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A simple solvothermal route in a binary solution of triethylenetetramine (TETA) and deionized water (DIW) has been used to synthesize hierarchical hollow Co(9)S(8) microspheres with high surface area (80.38 m(2) g(-1)). An appropriate volume ratio of TETA:DIW has been found to be essential for the formation of hollow Co(9)S(8) microspheres.

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Solubility and stability of lead arsenates at 25 degrees C.

J Environ Sci Health A Tox Hazard Subst Environ Eng

November 2009

Lead arsenates were the most extensively used arsenical insecticides in the past. Their residues, especially the water-soluble fractions in environment may pose a potential human health risk. The solubility products (K(sp)) and free energies of formation (Delta G(f) degrees) of PbHAsO(4).

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As pigs are susceptible to both human and avian influenza viruses, they have been proposed to be intermediate hosts or mixing vessels for the generation of pandemic influenza viruses through reassortment or adaptation to the mammalian host. In this study, we reported avian-like H1N1 and novel ressortant H1N2 influenza viruses from pigs in China. Homology and phylogenetic analyses showed that the H1N1 virus (A/swine/Zhejiang/1/07) was closely to avian-like H1N1 viruses and seemed to be derived from the European swine H1N1 viruses, which was for the first time reported in China; and the two H1N2 viruses (A/swine/Shanghai/1/07 and A/swine/Guangxi/13/06) were novel ressortant H1N2 influenza viruses containing genes from the classical swine (HA, NP, M and NS), human (NA and PB1) and avian (PB2 and PA) lineages, which indicted that the reassortment among human, avian, and swine influenza viruses had taken place in pigs in China and resulted in the generation of new viruses.

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