Publications by authors named "Hui-Jie Yuan"
Article Synopsis
- ARNT is a transcription factor linked to cellular stress responses, but its role in cutaneous squamous cell carcinoma (cSCC) is not well understood.
- The study found that ARNT is downregulated in cSCC and precancerous lesions, and reducing ARNT levels enhanced cell growth and metastasis in laboratory settings.
- Results indicate that ARNT regulates cSCC proliferation and invasiveness through the CXCL3 pathway, suggesting it could be a promising target for cSCC treatment.
Unlabelled: Pemphigus is a complex dermatologic autoimmune bullous disease whose pathogenic mechanism is not fully understood. Anti-desmoglein-1 (Dsg1) and anti- Dsg3 autoantibodies play an important role in the pathogenesis of pemphigus.
Objectives: To investigate the role of T-helper17 (Th17) and regulatory T (Treg) cells in the pathogenesis of pemphigus in fifty-one patients and twenty-six healthy individuals (control group).