Downregulation of ERRα inhibits angiogenesis in human umbilical vein endothelial cells through regulating VEGF production and PI3K/Akt/STAT3 signaling pathway.

The human estrogen related receptor α (ERRα) is a pivotal regulator involved in energy homeostasis and mitochondrial biogenesis. It has been demonstrated that activation of ERRα in various breast cancer cells results in a significant increase of vascular endothelial growth factor (VEGF) mRNA and protein secretion. However, little is known about the relationship between ERRα and angiogenesis.

Minimally traumatic midface lift approach for patients in their early 30s and 40s.

Background: To evaluate the effectiveness of the minimally traumatic midface lift approach in combination with the Wrinkle Severity Rating Scale (WSRS) criteria.

Methods: From July 2007 to September 2009, 21 female patients underwent the minimal incision midface lift procedure. The procedure was mainly composed of a small arrow-like incision just superior to the top of the auricle, a fanlike subcutaneous dissection, and 3 suspension sutures.