Publications by authors named "Hui-Hong Dou"
Objective: This study investigates the causal relationship between gut microbiota, inflammatory cytokines, and Kawasaki disease (KD), and whether cytokines mediate the effect of gut microbiota on KD.
Methods: A Mendelian randomization analysis using the inverse-variance weighted method assessed the causal effects of gut microbiota and inflammatory cytokines on KD and explored potential mediation.
Results: The study found causal links between 20 types of gut microbiota and KD.
Background: To explore the relationship between vitamin D levels and risk of SARS-CoV-2 infection and its severity in children and adolescents, and provide a theoretical basis for clinical practice.
Methods: The PubMed, Web of Science, Embase, MEDLINE, and Cochrane Library databases were searched for comprehensive cohort and case-control studies on the association between childhood vitamin D deficiency and the risk and prognosis of coronavirus disease-2019 (COVID-19). The search period was set from December 1, 2019, to December 31, 2023.
Impact of Gut Microbiota and Inflammatory Cytokines on Immune Thrombocytopenia.
Eur J Haematol
January 2025
Article Synopsis
- Immune thrombocytopenic purpura (ITP) is an autoimmune disorder possibly influenced by gut microbiota and inflammatory cytokines, but the relationships are not fully understood.
- A study utilized Mendelian randomization to explore the causal links between gut microbiota and ITP, finding 11 microbiota species that increase ITP risk and 12 that decrease it.
- The research identified CXCL10, CXCL5, and VEGF-A as key inflammatory cytokines mediating the effects of certain gut microbiota on ITP, suggesting new potential targets for treatment and prevention.
Objectives: To systematically analyze adverse events (AEs) in treatment of spinal muscular atrophy (SMA) with Nusinersen in children and adolescents.
Methods: The study is registered on PROSPERO (CRD42022345589). Databases were searched and literature relating to Nusinersen in the treatment of spinal muscular atrophy in children from the start of database establishment to December 1, 2022, was retrospectively analyzed.
Objectives: To understand the global incidence of the adverse events associated with fecal microbiota transplantation (FMT) in children over the past 20 years.
Methods: We searched PubMed, Web of Science, Embase, and three Chinese databases (CNKI, Wanfang, and Chongqing Weipu) for high-quality articles written over the past 20 years and made selections based on the quality standard score. The study characteristics and incidences of adverse events were extracted from each article, meta-analysis was performed using the R.