Publications by authors named "Hui-Fang Du"

Apple ring rot, caused by the pathogenic fungus , has inflicted substantial economic losses and caused significant food safety concerns. In this study, a pimarane-type diterpenoid, diaporthein B (DTB), isolated from a marine-derived fungus, exhibited significant antifungal activity against , with an EC value of 8.8 μg/mL.

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  • Two new diketopiperazine alkaloids, penipiperazine A (1) and its related metabolite (2), along with a known compound (3), were obtained from Penicillium brasilianum and their structures were analyzed using various spectroscopic methods.
  • Compounds 1 and 2 showed promising anti-inflammatory effects by inhibiting nitric oxide release and pro-inflammatory cytokine expression in lab tests, indicating their potential for further development as anti-inflammatory agents.
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  • The text discusses various types of agricultural pathogenic fungi, including species like Fusarium and Phytophthora, which pose a threat to crops globally and impact agricultural production and economics.
  • It highlights the potential of marine-derived fungi to produce unique natural compounds that exhibit antifungal properties effective against different agricultural pathogens.
  • The review summarizes the antifungal activities of 198 secondary metabolites from marine fungal sources, citing 92 references from 1998 to 2022 to analyze their structure and distribution.
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Ligand-mediated interface control has been broadly applied as a powerful tool in constructing asymmetric multicomponent nanoparticles (AMNP), and induces the anisotropic growth with fine-tuning morphology, composition, plasmonic property and functionality. As a new kind of AMNP, the synthesis of Janus Au-Ag nanoparticles with tunable negative surface curvature is still a challenge. Here, we demonstrate that the synergistic surface energy effects between gold nanodumbbells (Au NDs) with a negative surface curvature and 4-mercaptobenzoic acid (4-MBA) can direct the site-selective growth of anisotropic silver domains on gold nanodumbbells (Au NDs@Ag NPs).

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Objective: The efficacy and safety of minimally invasive nephrolithotomy (MPCNL) versus retrograde intrarenal surgery (RIRS) was assessed for lower calyceal (LC) stones.

Methods: Our team conducted a systematic literature search up to December, 2022, using PUBMED, EMBASE and the Cochrane Library. The study was registered in PROSPERO, CRD 42021247197.

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  • Three new polyketides, eutyketides A and B, and cytosporin X, were isolated from a marine-derived fungus, along with four known compounds.
  • The structures of eutyketides A and B were determined using advanced methods like HRMS and NMR, while their absolute configurations were confirmed through electronic circular dichroism (ECD) analysis.
  • All isolated compounds were tested for anti-inflammatory effects, with eutyketides A and B showing significant inhibition of nitric oxide production in macrophages at a concentration of 50.0 µg/mL.
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Aquatic pathogens, including Vibrio, Edwardsiella, Pseudomonas, and Aeromonas, which could result in bacterial diseases to aquaculture, have seriously threatened the world aquaculture production. Marine-derived fungi, which could produce novel secondary metabolites with significant antibacterial activity, may be an important source for finding effective agents against aquatic pathogens. In this review, a systematically overview of the harm of several aquatic pathogens, and 134 antibacterial secondary metabolites against aquatic pathogens from 13 genera of marine-derived fungi, were summarized and concluded.

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  • A new compound called talasteroid, a withanolide, was discovered alongside a known steroid and eight meroterpenoids from a marine-derived fungus.
  • The structures and configurations of these compounds were identified using advanced techniques like NMR spectroscopy and X-ray diffraction.
  • Talasteroid is the first withanolide to have a unique 4-substituted 2,3-dimethyl-2-butenolide ring, and the researchers also tested the compounds for their antimicrobial and antioxidant properties.
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Objective: To develop the certified reference material of mercury in lyophilized human urine.

Methods: Human urine samples from normal level mercury districts were filtered, homogenized, dispensed, lyophilized and radio-sterilized. Homogeneity test, stability inspection and certification were conducted using a atom fluorescence spectrophotometric method.

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Objective: To understand the the residents' knowledge, behavior and attitude of influenza A (H1N1) in Shuangqiao District of Chengde city, and provide the basis for making proper strategies of health education, prevention and control on influenza A (H1N1).

Methods: 211 residents from 1 community and 1 village of Shuangqiao District were selected to participate the questionnaire interview with multi-stage clustering sampling.

Results: 97.

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EDCs are new generation of environmental pollutions which are globally concerned. They may cause adverse effect mainly to the endocrine system and nervous system, etc. To assess the EDCs' hazard to the health exactly, we should know about the distribution and level of EDCs in the environment.

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