Design and performance analysis of multi-enzyme activity-doped nanozymes assisted by machine learning.

Traditional design approaches for nanozymes typically rely on empirical methods and trial-and-error, which hampers systematic optimization of their structure and performance, thus limiting the efficiency of developing innovative nanozymes. This study leverages machine learning techniques supported by high-throughput computations to effectively design nanozymes with multi-enzyme activities and to elucidate their reaction mechanisms. Additionally, it investigates the impact of dopants on the microphysical properties of nanozymes.

Estimation of Knee Joint Angle from Surface EMG Using Multiple Kernels Relevance Vector Regression.

In wearable robots, the application of surface electromyography (sEMG) signals in motion intention recognition is a hot research issue. To improve the viability of human-robot interactive perception and to reduce the complexity of the knee joint angle estimation model, this paper proposed an estimation model for knee joint angle based on the novel method of multiple kernel relevance vector regression (MKRVR) through offline learning. The root mean square error, mean absolute error, and R2_score are used as performance indicators.

The ketogenic diet increases Neuregulin 1 expression via elevating histone acetylation and its anti-seizure effect requires ErbB4 kinase activity.

Background: The ketogenic diet (KD)has been considered an effective treatment for epilepsy, whereas its underlying mechanisms remain obscure. We have previously reported that the KD feeding increased Neuregulin 1 (NRG1) expression in the hippocampus; disruption of NRG1 signaling by genetically deleting its receptor-ErbB4 abolished KD's effects on inhibitory synaptic activity and seizures. However, it is still unclear about the mechanisms underlying the effect of KD on NRG1 expression and whether the effects of KD require ErbB4 kinase activity.

Neuregulin 1/ErbB4 signaling contributes to the anti-epileptic effects of the ketogenic diet.

Background: The ketogenic diet (KD) has been recognized as a potentially effective therapy to treat neuropsychiatric diseases, including epilepsy. Previous studies have indicated that KD treatment elevates γ-Amino butyric acid (GABA) levels in both human and murine brains, which presumably contributes to the KD's anti-seizure effects. However, this has not been systematically investigated at the synaptic level, and the underlying molecular mechanisms remain to be elucidated.

A NaI(Tl)-based radioactive noble-gas monitoring system used for radiation monitoring.

Radioactive noble-gas monitoring is necessary in nuclear facilities. A NaI(Tl)-based radioactive noble-gas monitoring system was developed. In order to increase the amount of air to be measured, the sample vessel of this system was larger than that of other systems, and was pressurized to about 5 × 10 Pa.

A continuous plutonium aerosol monitor for use in high radon environments.

Radon concentration is very high in underground basements and other facilities. Radon concentration in a nuclear facility locates in the granite tunnel can be as high as 10(4) Bq m(-3) in summer. Monitoring plutonium aerosol in this circumstance is seriously interfered by radon daughters.

[Early diagnosis and microsurgical treatment of hand glomus tumor in 30 female cases].

Objective: To investigate the clinical features, early diagnosis and surgical treatment of the hand glomus tumor in the female.

Methods: Thirty female patients with the hand glomus tumor underwent early resection by microsurgery. The average age was 35 years ranging from 18 to 48 years.