Exploring the complex relationship between metabolomics and breast cancer early detection (Review).

An overview of metabolomics in cancer research, focusing on the identification of biomarkers, pharmacological targets and therapeutic agents, is provided in the present review. The fundamentals of metabolomics, the role of metabolites in cancer emergence and the methods used in metabolomic analysis, are reviewed. The applications of metabolomics in cancer therapy and diagnostics, as well as the challenges encountered in metabolomic research, are discussed.

Nonpharmacological mental health interventions for adolescent patients with polycystic ovary syndrome: a scoping review.

Objectives: This study aimed to summarize nonpharmacological mental health interventions that are beneficial for adolescent patients with polycystic ovary syndrome (PCOS) and to identify the limitations of existing studies.

Material And Methods: Following the recommendations of the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-SCR), we conducted a scoping review of nonpharmacological interventions aimed at improving mental health in adolescents with PCOS.

Results: Six randomized controlled trials (RCTs), two quasiexperimental studies, two case reports, one prospective study, one predictive correlation study, and one field trial study were included, resulting in 13 articles.

Retinal Vascular Morphology Reflects and Predicts Cerebral Small Vessel Disease: Evidences from Eye-Brain Imaging Analysis.

Cerebral small vessel disease (SVD) involves ischemic white matter damage and choroid plexus (CP) dysfunction for cerebrospinal fluid (CSF) production. Given the vascular and CSF links between the eye and brain, this study explored whether retinal vascular morphology can indicate cerebrovascular injury and CP dysfunction in SVD. We assessed SVD burden using imaging phenotypes like white matter hyperintensities (WMH), perivascular spaces, lacunes, and microbleeds.

Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19.

Background: COVID-19 continues to show long-term impacts on our health. Limited effective immune-mediated antiviral drugs have been launched.

Methods: We conducted a Mendelian randomization (MR) and colocalization analysis using 26,597 single-cell expression quantitative trait loci (sc-eQTL) to proxy effects of expressions of 16,597 genes in 14 peripheral blood immune cells and tested them against four COVID-19 outcomes from COVID-19 Genetic Housing Initiative GWAS meta-analysis Round 7.

Ambient air pollution exposure in relation to cerebral small vessel disease in Chinese population: A cranial magnetic resonance imaging-based study.

Cerebral small vessel disease (CSVD), a chronic and progressive vascular disorder closely associated with stroke and dementia, is primarily identified and diagnosed in cranial magnetic resonance imaging (MRI). Given the limited evidence on the relationship between air pollution and CSVD, this study aimed to investigate the links between multiple air pollutants exposure and CSVD risk. Eligible subjects and their cranial MRI data were obtained from the Multi-modality Medical Imaging Study Based on Kailuan Study, totaling 1216 participants.

Effect of cetuximab plus FOLFOX4 regimen on clinical outcomes in advanced gastric carcinoma patients receiving evidence-based care.

Background: Although chemotherapy is effective for treating advanced gastric carcinoma (aGC), it may lead to an adverse prognosis. Establishing a highly effective and low-toxicity chemotherapy regimen is necessary for improving efficacy and outcomes in aGC patients.

Aim: To determine the efficacy and safety of cetuximab (CET) combined with the FOLFOX4 regimen (infusional fluorouracil, folinic acid, and oxaliplatin) as first-line therapy for patients with aGC, who received evidence-based care (EBC).

Associations of serum uric acid variability with neuroimaging metrics and cognitive decline: a population-based cohort study.

Background: The relationship between variation in serum uric acid (SUA) levels and brain health is largely unknown. This study aimed to examine the associations of long-term variability in SUA levels with neuroimaging metrics and cognitive function.

Methods: This study recruited 1111 participants aged 25-83 years from a multicenter, community-based cohort study.

Gray matter volume mediates the association of long-term blood pressure variability with cognitive function in an adult population.

Introduction: We delineated the associations among long-term blood pressure variability (BPV), brain structure, and cognitive function.

Methods: We included 1254 adult participants from the Kailuan study. BPV was calculated from 2006 to 2020.

Hippocampal volume mediates the association of arterial stiffness with cognitive impairment in adult population.

Objectives: To investigate the association of arterial stiffness with brain perfusion, brain tissue volume and cognitive impairment in the general adult population.

Materials And Methods: This prospective study included 1488 adult participants (age range: 22.8-83.

Silencing DDX3 Attenuates Interleukin-1β-Induced Intervertebral Disc Degeneration Through Inhibiting Pyroptosis.

Intervertebral disc degeneration (IVDD) is a common disorder associated with chronic inflammation and cell death. In this study, an IVDD rat model was created through Interleukin-1β (IL-1β) injection. The degeneration of intervertebral disc tissues was assessed using magnetic resonance imaging (MRI), followed by hematoxylin and eosin (H&E) and terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) staining.

Serum uric acid is associated with midbrain enlarged perivascular spaces: Results from Multi-modality Medical imaging sTudy bAsed on KaiLuan Study (META-KLS).

Background: Serum uric acid (SUA) is a major cause of cardiovascular and cerebrovascular diseases. Whether and to what extent the excess risk of enlarged perivascular spaces (EPVS) conferred by SUA is unknown. The study was conducted to investigate the association between SUA and EPVS in different brain regions.

Association between Body Mass Index and Brain Health in Adults: A 16-Year Population-Based Cohort and Mendelian Randomization Study.

The cumulative effect of body mass index (BMI) on brain health remains ill-defined. The effects of overweight on brain health across different age groups need clarification. We analyzed the effect of cumulative BMI on neuroimaging features of brain health in adults of different ages.

Characterization of Novel PHEX Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation.

Background: X-linked hypophosphatemia (XLHR) is the most common genetic form of hypophosphatemic rickets (HR), which is caused by phosphate regulating endopeptidase homolog X-linked (PHEX) gene mutation. At present, the genotype-phenotype relationship of XLHR and the pathogenic role of PHEX are not fully understood.

Methods: In this study, we summarized clinical features in a new cohort of 49 HR patients and detected 16 novel PHEX and 5 novel non-PHEX variants.

Association of variability in body size with neuroimaging metrics of brain health: a population-based cohort study.

Background: The relationship between the fluctuation in body size and brain health is poorly understood. This study aimed to examine the associations of long-term variability in body mass index (BMI) and waist-to-hip ratio (WHR) with neuroimaging metrics that approximate brain health.

Methods: This cohort study recruited 1114 participants aged 25-83 years from a multicenter, community-based cohort study in China.

The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study.

Background: As the retinal microvasculature shares similarities with the cerebral microvasculature, numerous studies have shown that retinal vascular is associated with cognitive decline. In addition, several population-based studies have confirmed the association between retinal vascular and cerebral small vessel disease (CSVD) burden. However, the association of retinal vascular with CSVD burden as well as cognitive function has not been explored simultaneously.

Ocular biomarkers of cognitive decline based on deep-learning retinal vessel segmentation.

Background: The current literature shows a strong relationship between retinal neuronal and vascular alterations in dementia. The purpose of the study was to use NFN+ deep learning models to analyze retinal vessel characteristics for cognitive impairment (CI) recognition.

Methods: We included 908 participants from a community-based cohort followed for over 15 years (the prospective KaiLuan Study) who underwent brain magnetic resonance imaging (MRI) and fundus photography between 2021 and 2022.

Diverse Listeria monocytogenes in-house clones are present in a dynamic frozen vegetable processing environment.

Listeria (L.) monocytogenes is of global concern for food safety as the listeriosis-causing pathogen is widely distributed in the food processing environments, where it can survive for a long time. Frozen vegetables contaminated with L.

Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies.

Osteosarcoma is a highly aggressive and metastatic malignant tumor. It has the highest incidence of all malignant bone tumors and is one of the most common solid tumors in children and adolescents. Osteosarcoma tissues are often richly infiltrated with inflammatory cells, including tumor-associated macrophages, lymphocytes, and dendritic cells, forming a complex immune microenvironment.

Enlarged Perivascular Spaces in Relation to Cumulative Blood Pressure Exposure and Cognitive Impairment.

Background: Hypertension and enlarged perivascular spaces (EPVS) are thought to be associated with cognitive impairment. However, the correlations among hypertension, EPVS, and cognitive impairment have not been studied yet. We aimed to investigate the relationships between cumulative blood pressure (cBP) exposure with EPVS and cognitive impairment and whether EPVS may mediate the relationship between cBP and cognitive impairment.