Strategy for Fabricating Degradable Low-Surface-Energy Cross-Linked Networks with Excellent Anti-Fouling Properties.

Marine biofouling negatively impacts marine industries and ship navigation. However, current coatings are based on a single antifouling mechanism, which is insufficient to cope with the complex and ever-changing marine environment. Herein, multifunctional antifouling coatings were developed using a material system containing perfluoropolyether and caprolactone chains.

Supplemental glucose oxidase as an antibiotic substitute alleviates diarrhea and improves intestinal health in weaned piglets.

Weaning stress-induced diarrhea is a serious issue in pig production. This study aimed to evaluate the potential of glucose oxidase (GOD) as an antibiotic substitute to alleviate diarrhea and improve gut health in weaned piglets. According to a randomized complete block design, 250 piglets weaned around 21 d of age were allocated into 5 groups (5 replicates/group), which received a basal diet without or with supplemental 200 mg/kg antibiotic, 500, 1000 and 2000 U/kg GOD, respectively.

The expression of CCL17 and potential prognostic value on tumor immunity in thyroid carcinoma based on bioinformatics analysis.

Although CCL17 has been reported to exert a vital role in many cancers, the related studies in the thyroid carcinoma have never reported. As a chemokine, CCL17 plays a positive role by promoting the infiltration of immune cells into the tumor microenviroment (TME) to influence tumor invasion and metastasis. Therefore, this study is aimed to investigate the association of CCL17 level with potential prognostic value on tumor immunity in the thyroid carcinoma (THCA) based on the bioinformatics analysis.

Design of upper limb muscle strength assessment system based on surface electromyography signals and joint motion.

Purpose: This study aims to develop a assessment system for evaluating shoulder joint muscle strength in patients with varying degrees of upper limb injuries post-stroke, using surface electromyographic (sEMG) signals and joint motion data.

Methods: The assessment system includes modules for acquiring muscle electromyography (EMG) signals and joint motion data. The EMG signals from the anterior, middle, and posterior deltoid muscles were collected, filtered, and denoised to extract time-domain features.

Expanding horizons: genetic code expansion technology in the study of PTM functions.

Recent advancements in Genetic Code Expansion (GCE) have significantly enhanced our understanding of post-translational modifications (PTMs), which are critical for protein regulation. GCE facilitates the precise incorporation of unnatural amino acids (UAAs) at specific sites within proteins of interest (POIs), making it a powerful tool for modulating PTMs in vivo. This review summarizes the various UAAs utilized to directly incorporate PTMs into proteins through GCE, with a focus on their applications in both histone and non-histone PTMs research.

Aloe-emodin plus TIENAM ameliorate cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating microbiota.

Despite the high sepsis-associated mortality, effective and specific treatments remain limited. Using conventional antibiotics as TIENAM (imipenem and cilastatin sodium for injection, TIE) is challenging due to increasing bacterial resistance, diminishing their efficacy and leading to adverse effects. We previously found that aloe-emodin (AE) exerts therapeutic effects on sepsis by reducing systemic inflammation and regulating the gut microbiota.

Fractional Carbon Dioxide Laser Combined with Secukinumab in the Treatment of Refractory Psoriasis Lesions on the Lower Legs.

Psoriasis is a chronic autoimmune skin disorder characterized by high morbidity and a tendency for recurrence. Although biologic therapy for lesion clearance can achieve PASI 90/100, refractory sites remain challenging to completely clear, particularly on the lower legs and elbows. To explore the efficacy of novel treatments for these resistant sites, we present a clinical observation on the safety and effectiveness of fractional carbon dioxide (CO2) laser therapy combined with secukinumab for four patients with moderate-to-severe plaque psoriasis.

Crosstalk between gut microbiota and cancer chemotherapy: current status and trends.

Background: Chemotherapy is crucial in the management of tumors, but challenges such as chemoresistance and adverse reactions frequently lead to therapeutic delays or even premature cessation. A growing body of research underscores a profound connection between the gut microbiota (GM) and cancer chemotherapy (CC). This paper aims to pinpoint highly influential publications and monitor the current landscape and evolving trends within the realm of GM/CC research.

Combined Abrocitinib and Acitretin Therapy for Darier's Disease: A Case Report.

Darier's disease (DD) is a rare chronic keratinizing skin disease characterized by dyskeratosis of epidermal cells. We report a case of DD with a medical history spanning over 20 years and recurring symptoms. Pathologically confirmed DD was treated with a combination of abrocitinib and acitretin, resulting in rapid symptom resolution within 2 weeks.

Evaluating the diagnostic performance of [F]ALF-NOTA-FAPI-04 PET/CT in gastric cancer: a comparative study with [F]FDG PET/CT.

Purpose: To compare the diagnostic value of [F]ALF-NOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) and F-fluorodeoxyglucose (FDG) PET/CT in gastric cancer.

Methods: This single-center retrospective analysis included 65 patients with gastric cancer who received both [F]FDG and [F]ALF-NOTA-FAPI-04 PET/CT for initial staging or restaging. Histopathological manifestations, typical imaging manifestations, follow-up imaging, and comprehensive clinical assessment were used as reference criteria.

Hidden blood loss of minimally invasive transforaminal lumbar interbody fusion of lumbar degenerative diseases in patients with osteoporosis: a retrospective study.

Background: To compare hidden blood loss (HBL) of minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF) of lumbar degenerative diseases in patients with or without osteoporosis (OP) and identify the risk factors for HBL with OP.

Methods: The data from 156 patients with lumbar degenerative diseases, who underwent Mis-TLIF between January 2018 and December 2021, were retrospectively analyzed. The patients were divided into the Osteoporosis and Non-osteoporosis groups.

Impact of fat intake on [F]AlF-NOTA-FAPI-04 uptake in normal abdominal organs.

Purpose: [F]AlF-NOTA-FAPI-04 demonstrates significant physiological uptake in the gallbladder and biliary tract system, representing a limitation of this positron emission tomography (PET) tracer. The aim of this study was to evaluate the impact of milk consumed prior to a PET/CT scan on [F]AlF-NOTA-FAPI-04 uptake in normal abdominal organs.

Materials And Methods: A total of 86 patients who underwent [F]AlF-NOTA-FAPI-04 PET/CT imaging took part in this single-center retrospective clinical study at the Hunan Cancer Hospital between December 2020 and August 2021.

Subcellular Proteomic Mapping of Lysine Lactylation.

Protein lactylation is a novel post-translational modification (PTM) involved in many important physiological processes such as macrophage polarization, immune regulation, and tumor cell growth. However, traditional methodologies for studying lactylation have predominantly relied on peptide enrichment from whole-cell lysates, which tend to favor the detection of high-abundance peptides, thus limiting the identification of low-abundance lactylated peptides. To address this limitation, here, we employed subcellular fractionation to separate proteins and map lactylated peptides from each isolated subcellular fraction using a model cell line.

Effects of cricket powder on structural and mechanical properties of soy protein isolate extrudates.

This study investigated the impact of cricket powder (CP) incorporation on the structural and mechanical properties of soy protein isolate (SPI) extrudates. The physicochemical properties of CP, rheological properties of SPI-CP blends and their potential structuring properties were evaluated. The results showed that CP had a high protein content (72.

The Protective Effects of and Tenuifolin on Corticosterone-Evoked Ferroptosis, Oxidative Stress, and Neuroinflammation: Insights from Molecular Dynamics Simulations and In Vitro Experiments.

Excessive stress is a well-established contributor to neurological damage, insomnia, and depression, imposing a significant burden on individuals and society. This underscores the urgent need for effective stress-relief strategies. The main purpose of this study was to explore the protective effects of (PT) and its bioactive compound, tenuifolin, against corticosterone-induced neurotoxicity, with a focus on ferroptosis, oxidative stress, and neuroinflammation.

Host-derived alleviates hyperuricemia by improving gut microbial community and hydrolase-mediated degradation of purine nucleosides.

The gut microbiota is implicated in the pathogenesis of hyperuricemia (HUA) and gout. However, it remains unclear whether probiotics residing in the host gut, such as , can prevent HUA development. Herein, we isolated SQ001 from the cecum of HUA geese and conducted in vitro assays on uric acid (UA) and nucleoside co-culture.

Leech granules inhibit ferroptosis and alleviate renal injury in mice with diabetic kidney disease.

Ethnopharmacological Relevance: The underlying mechanisms of diabetic kidney disease (DKD) and effective treatment strategies remain unclear. DKD progression is closely associated with abnormal iron metabolism and ferroptosis in vivo. Leeches, used in traditional Chinese medicine for promoting blood circulation and resolving blood stasis, are utilized to treat diabetes and its associated complications.

Atomically Precise Design of PtSn Catalyst for the Understanding of the Role of Sn in Propane Dehydrogenation.

Propane dehydrogenation (PDH), an atom-economic reaction to produce high-value-added propylene and hydrogen with high efficiency, has recently attracted extensive attention. The severe deactivation of Pt-based catalysts through sintering and coking remains a major challenge in this high-temperature reaction. The introduction of Sn as a promoter has been widely applied to improve the stability and selectivity of the catalysts.

Porous fluorine-cerium nanosheets anchored with FeOOH quantum dots for synergistic enhanced visible-light-driven photo-Fenton degradation of phenol.

The utilization of two-dimensional (2D) materials to construct heterogeneous catalysts provides opportunities for environmental remediation, while the incorporation of porous structures can further enhance catalytic performance. In this work, a porous 2D FeOOH/fluorine-cerium (F-Ce) nanosheet composite was designed and synthesized by a simple impregnation-precipitation method. The unique 2D porous structure of F-Ce promoted the high dispersion of FeOOH quantum dots (QDs) (∼1.

How does the position of the pelvis and femur influence the selection of prosthesis size during 2D preoperative planning for total hip arthroplasty?

Purpose: Total Hip Arthroplasty (THA) is the primary treatment for hip diseases today. Nevertheless, total hip arthroplasty has its challenges, and one of these challenges is the potential for incorrect execution of the preoperative planning process. Such errors can lead to complications such as loosening and instability of the prosthesis and leg length discrepancy.

The actor-partner interdependence model of fertility stress and marital quality among couples undergoing in vitro fertilization and embryo transfer: The mediating role of dyadic coping.

To explore the relationships among fertility stress, dyadic coping and marital quality in couples undergoing in vitro fertilization-embryo transfer (IVF-ET). Couples receiving IVF-ET treatment at the clinic of the reproductive medicine centre of a hospital in China from February 2023 to October 2023 were selected by convenience sampling. A general information questionnaire, the Infertility Fertility Stress Scale (COMP-FPSS-SF), the dyadic coping inventory, and the marital adjustment test were used to evaluate the results.