Publications by authors named "Hui Wang-Heaton"
Aims: Published work has shown that ataxia-telangiectasia mutated kinase (ATM) deficiency is associated with cardioprotective effects in Western-type diet (WD)-fed female mice. This study assessed the expression of proteins related to fatty acid oxidation (FAO) and oxidative stress in WD-fed male and female mouse hearts, and investigated if sex-specific cardioprotective effects in WD-fed female ATM-deficient mice are maintained following myocardial infarction (MI).
Main Methods: Wild-type (WT) and ATM-deficient (hKO) mice (both sexes) were placed on WD for 14 weeks.
Article Synopsis
- Hyperactivation of PARP1 can lead to cell death when there is too much calcium, often seen in certain diseases.
- A study found that ATR kinase helps stop this cell death by controlling PARP1 during calcium overload.
- ATR does this by adding a special tag to PARP1, which makes it unable to cause necrosis, even without any DNA damage happening right away.