Publications by authors named "Hui Tao"

To investigate the anti-bacterial and anti-inflammatory properties of sophoridine and elucidate its mechanism of action, we carried out both in vitro and in vivo experiments. Multiple bacterial strains were utilized to determine the effective concentration of sophoridine in antibacterial and bactericidal assays. Subsequently, LPS-stimulated RAW264.

View Article and Find Full Text PDF

Aflatoxin B1 (AFB1) and zearalenone (ZEN) are the most prevalent mycotoxins in production, posing a serious threat to human and animal health. Therefore, it is very urgent to find a safe and efficient method for the biodegradation of these mycotoxins. Our previous study demonstrated that Bacillus subtilis ZJ-2019-1 moderately degrades both mycotoxins in vitro and ZEN in female gilts.

View Article and Find Full Text PDF

Background: We aimed to develop and validate an Artificial Intelligence (AI) model that leverages CCTA and optical coherence tomography (OCT) images for automated analysis of plaque characteristics and coronary function.

Methods: A total of 100 patients who underwent invasive coronary angiography, OCT, and CCTA before discharge were included in this study. The data were randomly divided into a training set (80 %) and a test set (20 %).

View Article and Find Full Text PDF

Background And Aims: Metals serve as co-factors for a host of metalloenzymes involved in mitochondrial metabolic reprogramming. Modifications in metal homeostasis are linked to epigenetic mechanisms. However, the epigenetic mechanisms through which metal affects cardiac fibrosis (CF) remain poorly understood.

View Article and Find Full Text PDF

Background: Posterior hemivertebra resection for hemivertebra deformities has been widely reported. However, achieving adequate correction of deformities through conventional hemivertebra resection remains technically challenging in older children. The authors developed a technique combining posterior hemivertebra extended resection with concave anterior column reconstruction.

View Article and Find Full Text PDF

Liver fibrosis is characterized by an excessive accumulation of extracellular matrix (ECM) and the activation of hepatic stellate cells (HSCs), which are influenced by epitranscriptomic and epigenetic factors. Recent advancements in epigenetic and epitranscriptomic research have revealed new opportunities for therapeutic interventions, particularly through the regulation of ferroptosis, a type of programmed cell death that is specifically linked to iron-dependent lipid peroxidation. In the context of liver fibrosis, a progressive scarring process that can progress to cirrhosis and ultimately end-stage liver disease, targeting these regulatory mechanisms to modulate ferroptosis presents a promising therapeutic strategy.

View Article and Find Full Text PDF

Lactic acid bacteria play a crucial role in maintaining the health of the host's gut microbiota. In this study, the anti-inflammatory properties of LR20-6 and L272 were evaluated using a mouse model of diarrhea induced by . We also investigated their effects on gut microbiota regulation.

View Article and Find Full Text PDF

Covalent-allosteric inhibitors (CAIs) may achieve the best of both worlds: increased potency, long-lasting effects, and reduced drug resistance typical of covalent ligands, along with enhanced specificity and decreased toxicity inherent in allosteric modulators. Therefore, CAIs can be an effective strategy to transform many undruggable targets into druggable ones. However, CAIs are challenging to design.

View Article and Find Full Text PDF

Efferocytosis is a mechanism by which phagocytes efficiently clear apoptotic cells, averting their secondary necrosis and the subsequent release of potentially immunogenic or cytotoxic substances that can trigger strong immune and inflammatory responses. During efferocytosis, the metabolic pathways of phagocytes are transformed, which, along with the catabolism of apoptotic cargo, can affect their function and inflammatory state. Extensive apoptosis occurs during placental development, and some studies reported the immunomodulatory effects of efferocytosis at the maternal-fetal interface.

View Article and Find Full Text PDF

Climate change and human activities affect the biomass of different algal and the succession of dominant species. In the past, phytoplankton phyla inversion has been focused on oceanic and continental shelf waters, while phytoplankton phyla inversion in inland lakes and reservoirs is still in the initial and exploratory stage, and the research results are relatively few. Especially for mid-to-high latitude lakes, the research is even more blank.

View Article and Find Full Text PDF

Objectives: The purpose of this study was to find the potential mechanism of two Lactobacillus ( L11 and LR) on ameliorating obesity, including lipid metabolism and gut microbiota. The two isolates have been studied to have good characterization in vitro, but in vivo studies in modulating lipid metabolism and gut microbiota were not studied.

Methods: In this study, mice with HFD supplemented with L11 or LR exhibited slower obesity progression, including reduced weight gain, abdominal fat accumulation, liver damage, inflammation, and adipose lesions.

View Article and Find Full Text PDF

Background: Photodynamic therapy (PDT) is beneficial for managing rosacea, and chlorin e6 derivative-mediated photodynamic therapy (STBF-PDT) has demonstrated efficacy in reducing acne lesions with mild adverse reactions.

Objectives: This study aimed to assess the effectiveness and safety of STBF-PDT for the treatment of moderate-to-severe rosacea.

Methods: In this prospective, randomised, evaluator-blind controlled study, patients with moderate-to-severe rosacea were assigned to receive up to six STBF-PDT sessions or 100 mg of doxycycline daily for eight weeks, followed by a 24-week follow-up.

View Article and Find Full Text PDF

The cyclic structure of non-ribosomal peptides (NRPs) is critical for enhancing their stability and bioactivity, which highlights the importance of exploring NRP cyclization enzymes for natural product discovery. Thioesterases (TEs) are crucial enzymes that catalyze the formation of various lactams, including macrolactams, β-lactams, and γ-lactams; however, their potential to produce other lactam types remains largely unexplored. In this study, we identified spinactin A () and novel derivatives, spinactin B-E (-), from NRRL 18395 and characterized the biosynthetic enzymes involved, particularly a unique TE SncF, responsible for δ-lactam formation.

View Article and Find Full Text PDF

Probiotics have been used in functional foods and dietary supplements, and in recent years, they have become more widely used in pets. In our previous experiment, L-27-2 and L-14-1 were isolated from cat feces and proved to have positive effects on lipid metabolism in mice. To further discuss their possible effects in cats, a total of 12 healthy cats (British Shorthair) were randomly divided into two groups.

View Article and Find Full Text PDF

A large number of cases of infectious colitis caused by multidrug-resistant (MDR) bacteria, such as , can result in colon damage and severe inflammation. Vanilla, a widely utilized flavor and fragrance compound, is extensively used in various food. However, the effect of vanilla on MDR -induced infectious colitis has received less attention.

View Article and Find Full Text PDF

Mitochondria, commonly referred to as "energy factories"of cells, play a crucial role in the function and survival of cardiomyocytes. However, as research on cardiac fibrosis has advanced, mitochondrial dysfunction(including changes in energy metabolism, calcium ion imbalance, increased oxidative stress, and apoptosis)is now recognized as a significant pathophysiological pathway involved in cardiac remodeling and progression, which also negatively affects the function and structure of the heart. In recent years, research focusing on targeting mitochondria has gained significant attention, offering new approaches for treating cardiac fibrosis.

View Article and Find Full Text PDF
Article Synopsis
  • Prebiotics play a crucial role in improving gut health and boosting immunity in animals, potentially enhancing beneficial bacteria growth.
  • The study examined the effects of lactobin and glucans combined with goat's milk on the gut health of 24 healthy cats, divided into four treatment groups.
  • Results showed that β-glucan significantly raised secretory immunoglobulin A (SIgA) levels in the blood and increased beneficial gut microbiota, indicating that β-glucan and lactobin might have promising prebiotic effects in cats.
View Article and Find Full Text PDF

Zearalenone (ZEN) has been detected in both pet food ingredients and final products, causing acute toxicity and chronic health problems in pets. Therefore, the early detection of mycotoxin contamination in pet food is crucial for ensuring the safety and well-being of animals. This study aims to develop a rapid and cost-effective method using an electronic nose (E-nose) and machine learning algorithms to predict whether ZEN levels in pet food exceed the regulatory limits (250 µg/kg), as set by Chinese pet food legislation.

View Article and Find Full Text PDF

The arid and semi-arid regions of northwest China are characterized by sparse vegetation and fragile ecosystems, making them highly susceptible to the impacts of climate change and human activities. Based on observed meteorological data, the Normalized Difference Vegetation Index (NDVI), the Lund-Potsdam-Jena dynamic global vegetation model (LPJ), a vegetation recovery potential model, and the MK trend test method, this study investigated the spatiotemporal distribution of vegetation recovery potential in northwest China and its relationship with global warming and increasing precipitation. The results indicated that vegetation in northwest China significantly increased, with greening closely related to trends in warming and wetting during 1982-2019.

View Article and Find Full Text PDF

Optical interconnects, leveraging surface plasmon modes, are revolutionizing high-performance computing and AI, overcoming the limitations of electrical interconnects in speed, energy efficiency, and miniaturization. These nanoscale photonic circuits integrate on-chip light manipulation and signal conversion, marking significant advancements in optoelectronics and data processing efficiency. Here, we present a novel plasmonic interconnect circuit, by introducing refractive index matching layer, the device supports both pure SPP and different hybrid modes, allowing selective excitation and transmission based on light wavelength and polarization, followed by photocurrent conversion.

View Article and Find Full Text PDF

More than half of the patients with type II diabetes mellitus (T2D) develop diabetic cardiomyopathy (DCM). Glycemic control alone cannot effectively prevent or alleviate DCM. Herein, we concentrated on the variations in levels of metabolites between DCM and T2D patients without cardiomyopathy phenotype.

View Article and Find Full Text PDF

In the process of cardiac fibrosis, the balance between the Wnt/β-catenin signalling pathway and Wnt inhibitory factor genes plays an important role. Secreted frizzled-related protein 3 (sFRP3), a Wnt inhibitory factor, has been linked to epigenetic mechanisms. However, the underlying role of epigenetic regulation of sFRP3, which is crucial in fibroblast proliferation and migration, in cardiac fibrosis have not been elucidated.

View Article and Find Full Text PDF

Background: The distribution of bone cement after percutaneous kyphoplasty (PKP) affects its clinical efficacy in patients with osteoporosis. Robotic and traditional treatment of osteoporotic vertebral compression fractures (OVCFs) have both been established as effective, but no studies have compared these 2 modalities in terms of bone cement distribution and clinical outcomes.

Objective: To compare the bone cement distribution and clinical efficacy of robot-assisted percutaneous kyphoplasty to those of fluoroscopy-assisted percutaneous kyphoplasty for the treatment of OVCFs.

View Article and Find Full Text PDF

Background: Large hepatocellular carcinoma (HCC) with a diameter ≥5 cm remains a significant challenge of poor survival and raises the need for prognosis evaluation. This study aimed to develop and validate a nomogram-based prognostic stratification to assess overall survival (OS) of patients with large HCC.

Methods: Data of patients with large HCC were retrospectively collected from the Surveillance, Epidemiology, and End Results (SEER) database and our hospital, and were divided into the training cohort, internal validation cohort and external validation cohort.

View Article and Find Full Text PDF