[Expression and Clinical Significance of Serum HDAC2 in Patients with Acute Myeloid Leukemia].

Objective: To investigate the expression of serum histone deacetylase 2 (HDAC2) in patients with acute myeloid leukemia (AML) and its clinical significance.

Methods: The 150 AML patients who received treatment in our hospital from April 2017 to April 2019 were included as AML group, and further divided into survival group (108 cases) and death group (42 cases) according to their survival status. In addition, 100 health individuals undergoing health examination in the same period were included as control group.

A dendritic cell-recruiting, antimicrobial blood clot hydrogel for melanoma recurrence prevention and infected wound management.

Surgical resection, the mainstay for melanoma treatment, faces challenges due to high tumor recurrence rates and complex postoperative wound healing. Chronic inflammation from residual disease and the risk of secondary infections impede healing. We introduce an innovative, injectable hydrogel system that integrates a multifaceted therapeutic approach.

[Overview of systematic reviews of Shufeng Jiedu Capsules].

At present, there have been many clinical trials and systematic reviews/Meta-analysis proving the good clinical efficacy of Shufeng Jiedu Capsules in the treatment of respiratory diseases, while comprehensive discussion is still required. This article overviews and analyzes the systematic reviews/Meta-analysis of Shufeng Jiedu Capsules to provide evidence support for clinical practice. The systematic reviews/Meta-analysis of Shufeng Jiedu Capsules were searched from CBM, Wanfang, CNKI, VIP, PubMed, EMbase and Cochrane Library.

Early Death and Survival of Patients With Acute Promyelocytic Leukemia in ATRA Plus Arsenic Era: A Population-Based Study.

Most randomized trials for acute promyelocytic leukemia (APL) have investigated highly selected patients under idealized conditions, and the findings need to be validated in the real world. We conducted a population-based study of all APL patients in Zhejiang Province, China, with a total population of 82 million people, to assess the generalization of all-trans retinoic acid (ATRA) and arsenic as front-line treatment. The outcomes of APL patients were also analyzed.

Efficacy of vitamin D plus calcium with/without alendronate on bone metabolism in immunologic thrombocytopenic purpura patients with steroid treatment: Nine-month results of a randomized, double-blinded, controlled trial.

Bone loss is a prominent complication in immunologic thrombocytopenic purpura (ITP) patients with steroid treatment. Anti-osteoporotic medications are applied as a therapeutic strategy to prevent bone deterioration in ITP patients. However, the skeletal protective effect of alendronate (ALN) in ITP patients has been rarely reported.

Fluorescent species formed by reaction of trinitroaromatics with N,N-dimethylformamide and hydroxide.

Trinitrobenzene (TNB) and trinitrotoluene (TNT) react in N,N-dimethylformamide (DMF) to form multiple species in solution. Despite structural similarities, electronic spectra show that the reactivity is different for TNB and TNT. In addition to reaction with the DMF solvent, residual water in nominally dry DMF generates sufficient hydroxide for reaction with TNB and TNT.

A category approach to predicting the hemolytic effects of ethylene glycol alkyl ethers in repeated-dose toxicity.

Categorizing chemicals is an approach with the potential to reduce animal testing for hazard assessment of chemicals. In this study we investigated the category approach for testing the hemolytic effects of ethylene glycol alkyl ethers (EGAEs) for repeated-dose toxicity (RDT). Using mechanistic information on the hemolytic effects of ethylene glycol butyl ether, a toxicologically meaningful category was built on the basis of similarity of metabolism, mode of action and the hemolytic effects of several EGAEs and related chemicals.

Identification of de novo STAT3 target gene in liver regeneration.

Unlabelled: The process of liver regeneration is regulated by complex mechanisms. Although signal transducer and activator of transcription-3 (STAT3), a transcription factor which targets mainly mitotic genes, definitely plays an important role in liver regeneration, the exact roles of STAT3 are not completely understood.

Aim: In this report, we tried to search for a new target of STAT3 involved in liver regeneration in mice.

Transcription factor AtMYB103 is required for anther development by regulating tapetum development, callose dissolution and exine formation in Arabidopsis.

Downregulation of the transcription factor AtMYB103 using transgenic technology results in early tapetal degeneration and pollen aberration during anther development in Arabidopsis thaliana. This paper describes the functional analysis of the AtMYB103 gene in three knock-out mutants. Two male sterile mutants, ms188-1 and ms188-2, were generated by ethyl-methane sulfonate (EMS) mutagenesis.

[Genetic mapping of rice gene OsALB23 regulating chloroplast development].

The biogenesis of chloroplast from proplastid is the prerequisite of photosynthesis. Using electron microscope, we found that rice albino mutant Osalb23 had no thylakoid inside the chloroplast, only some empty vesicles could be observed (Fig. 2).

[The ultrastructure of compound eye in the Portunus tritubereulatus under different wavelength lights adaptation].

The fine structure of compound eye in Portunus tritubereulatus under different wavelength lights adaptation was studied with electron microscopy. The Portunus tritubereulatus were trained in a darkroom for 30 minutes and they were given the lights of different wavelength (red 750 nm, yellow 580 nm, green 560 nm, blue 400 nm). The result showed that fine structures varied with different wavelength lights.

Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation of Mn-SOD.

Background/aims: Hypoxia/reoxygenation (H/R) causes oxidative stress to the cell and induces apoptotic cell death. Signal transducer and activator of transcription-3 (Stat3) is one of the most important molecules involved in the initiation of liver development and regeneration, and has recently been shown to protect cells against various pathogens. In order to investigate the hepatoprotective effects of Stat3, we examined whether it protects against H/R-induced injury in primary hepatocytes.

Comprehensive examination of gene expression associated with long-term stable graft acceptance by renal transplant recipients.

Expression levels of mRNA in peripheral blood mononuclear cells from five renal transplant recipients and five non-transplanted controls were analyzed with GeneChips (GeneChip Instrument system, Affymetrix, Santa Clara, CA, USA). All recipients had retained a well-functioning kidney graft for more than 15 yr on low-dose maintenance immunosuppression. Among a total of 12630 transcripts examined, significant differential expression was observed for 599 genes, whereby 470 genes were up-regulated and 129 down-regulated in the transplant recipients compared with controls.

Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms.

Signal transducer and activator of transcription-3 (Stat3) is one of the most important molecules involved in the initiation of liver development and regeneration. In order to investigate the hepatoprotective effects of Stat3, we examined whether Stat3 protects against Fas-mediated liver injury in the mouse. A constitutively activated form of Stat3 (Stat3-C) was adenovirally overexpressed in mouse liver by intravenous injection, and then a nonlethal dose of Fas agonist (Jo2) was injected intraperitoneally into the mouse (0.