Publications by authors named "Hui Lu"

Marine anammox bacteria-based Fe(II)-driven autotrophic denitratation and anammox (MFeADA) was investigated for nitrogen removal from saline wastewater for the first time. The study demonstrated that varying influent doses of Fe(II), which participate in the Fe cycle, significantly influenced nitrogen removal performance by altering the fate of nitrite. When 50 mg/L Fe(II) was added, the nitrogen removal was mainly performed by the anammox and Fe(II)-driven autotrophic denitratation (FeAD).

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Objective: To assess the prevalence and risk determinants of locomotive syndrome (LS) in geriatric cancer survivors in China. To generate evidence-based insights for the clinical prevention and intervention strategies concerning LS in this vulnerable population, emphasizing the need for integrated public health initiatives focused on maintaining mobility among geriatric cancer survivors.

Methods: Six hundred geriatric cancer survivors were recruited at a hospital in China.

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The gut microbiome affects the occurrence and development of metabolic diseases, with a significant amount of research focused on intestinal bacteria. As an important part of the gut microbiome, gut viruses were studied recently, particularly through fecal virome transplantation (FVT), revealing manipulating the gut virus could reverse overweight and glucose intolerance in mice. And human cohort studies found gut virome changed significantly in patients with metabolic disease.

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Dysregulated B-cell activation plays pivotal roles in IgG4-related disease (IgG4-RD), which makes B-cell depletion a potential strategy for IgG4-RD treatment. In this study, we aimed to investigate the feasibility of applying anti-CD19 chimeric antigen receptor T(CAR-T) cell therapy to IgG4-RD treatment in a mouse disease model based on LatY136F knock-in (Lat) mice. We constructed murine anti-CD19 CARs with either CD28 or 4-1BB as the intracellular costimulatory motif and evaluated the therapeutic function of the corresponding CAR-T cells by infusing them into Lat mice.

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Cosmetic dermal filling represents a significant advance in aesthetic medicine, providing non-invasive treatments with immediate and durable outcomes. Despite the generally safe nature of dermal fillers and avoidable complications with proper technique and planning, they are still risky, with potential complications varying from mild and transient to severe and enduring. This study introduces innovative strategies designed to decrease the risk of serious complications, such as vascular occlusion.

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Non-subungual glomus tumor in the fingers is very rare. To explore the insights gained from diagnosing and treating non-subungual glomus tumors in the finger, we collected 19 cases in the last ten years, which were only reported as isolated cases in the previous literature. This was a retrospective study of 19 surgical patients between May 2012 and January 2022 with preoperative MRI, ultrasound, and their final pathological diagnosis is glomus tumor, while the lesions were located not under the nail bed.

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Objective: Hypoxic-ischemic encephalopathy (HIE) is a major cause of perinatal brain injury. Creatine is a dietary supplement that can increase intracellular phosphocreatine to improve the provision of intracellular adenosine triphosphate (ATP) to meet the increase in metabolic demand of oxygen deprivation. Here, we assessed prophylactic fetal creatine supplementation in reducing acute asphyxia-induced seizures, disordered electroencephalography (EEG) activity and cerebral inflammation and cell death histopathology.

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Article Synopsis
  • - Schizophrenia (SCZ) patients experienced higher rates of SARS-CoV-2 infection and mortality during the COVID-19 pandemic compared to those with other mental disorders, but the reasons for this remain unclear.
  • - The review suggests that common molecular pathways linked to energy metabolism, immune disruptions, and central nervous system abnormalities may play a role in the heightened risks for SCZ patients during COVID-19.
  • - Additionally, factors such as sociodemographic challenges, limited access to psychiatric care, and barriers to vaccination were discussed as reasons behind the elevated infection and mortality rates in SCZ individuals.
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Cervical cancer is the most common gynecologic cancer. Autophagy is involved in the progression of CCa. ULK1 is a crucial kinase in autophagy initiation.

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Background: Heart rate (HR) monitoring is a medical standard to provide information about a patient's health status. In palliative care, relationship and social engagement are crucial therapeutic concepts. For fear of disrupting communication, social contact, and care, continuous HR monitoring is underutilised despite its potential to inform on symptom burden and therapeutic effects.

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Sorafenib, the targeted therapy for hepatocellular carcinoma (HCC), has been utilized in clinics for over a decade. However, its effectiveness is severely hindered by acquired drug resistance, the mechanisms of which remain largely elusive. In this study, we identify that carbonic anhydrase 2 (CA2) is a key regulator of sorafenib resistance.

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  • A study aimed to find better ways to trace central lymph nodes in patients with papillary thyroid carcinoma by comparing two methods of nanocarbon particle injection: preoperative ultrasound-guided injection versus intraoperative injection.
  • The research involved 302 patients, with results showing that preoperative injection led to fewer dye leaks and better staining of lymph nodes.
  • Preoperative ultrasound-guided injection was found to enhance the detection of specific lymph node types, especially in patients with certain thyroid conditions and larger tumors.
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  • The study examines brain samples from six Chinese brain banks to analyze the prevalence of various neuropathologies, filling a gap in existing research.
  • It found that a significant percentage of brains showed conditions like PART (35%), LATE (46%), and CVD (63%), with CVD potentially being the earliest contributor to these pathologies.
  • The results suggest that the prevalence of these disorders in China is comparable to global data, highlighting notable regional variations in disease occurrence and progression.
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  • - Exercise, specifically treadmill training, helps protect against Alzheimer's disease (AD) by improving cognitive function and reducing harmful proteins related to the disease, like amyloid-beta (Aβ) and hyperphosphorylated tau.
  • - In a rat study, researchers found that exercise boosts the expression of a protein called TRIM9, which plays a role in decreasing inflammation in the brain by inhibiting the NF-κB signaling pathway.
  • - These findings imply that TRIM9 could be a promising target for developing new treatment strategies aimed at reducing inflammation and cognitive decline in Alzheimer's patients.
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Background: Globally, adolescent depression is prevalent. There is, however, a dearth of studies investigating behavioral intention to professional help-seeking regarding mental health problems among adolescents having probable depression. Based on the Stress Coping Theory, the hypothesis that personal resources and active coping would mediate between interpersonal resources and behavioral intention to professional help-seeking was investigated.

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The aim of this study was to evaluate the effectiveness of A1 pulley reconstruction in treating severe trigger fingers and to compare its outcomes with those of the traditional A1 pulley release technique. A total of 43 patients participated in the study, divided into two groups: 22 patients underwent A1 pulley reconstruction, while the remaining 21 patients received the standard A1 pulley release procedure. The outcomes were assessed using the Michigan Hand Outcomes Questionnaire (MHQ) 1 month post-surgery.

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Strategies aimed at targeting fungal extracellular heat shock protein 90 (eHsp90) using vaccines and antibodies have demonstrated encouraging potential in the prevention and management of invasive fungal diseases (IFDs). However, the precise underlying mechanism by which eHsp90 contributes to the heightened virulence of Candida albicans (C. albicans) remains an enigma, awaiting further elucidation.

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Prohibited item detection in X-ray images is one of the most essential and highly effective methods widely employed in various security inspection scenarios. Considering the significant overlapping phenomenon in X-ray prohibited item images, we propose an anti-overlapping detection transformer (AO-DETR) based on one of the state-of-the-art (SOTA) general object detectors, DETR with improved denoising anchor boxes (DINO). Specifically, to address the feature coupling issue caused by overlapping phenomena, we introduce the category-specific one-to-one assignment (CSA) strategy to constrain category-specific object queries in predicting prohibited items of fixed categories, which can enhance their ability to extract features specific to prohibited items of a particular category from the overlapping foreground-background features.

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Article Synopsis
  • Plants hold many undiscovered natural products, especially minor bioactive components, which are challenging to identify due to the need for large amounts of plant material.
  • Mugwort is a well-known insect repellent herb, particularly used during China's Dragon Boat Festival, but the specific compound responsible for its repellency was previously unidentified.
  • This study used a new genetic approach to discover 54 terpene products from mugwort, including a novel compound, and found that (+)-intermedeol is highly effective against mosquitoes and ticks, achieving initial production in a yeast system.
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The potential relationship between type 2 diabetes (T2D) and candidiasis is of concern due to the respective characteristics of these conditions, yet the exact causal link between the two remains uncertain and requires further investigation. In this study, the inverse-variance-weighted (IVW) analysis indicated a significant genetic causal relationship between T2D and candidiasis ( = 0.0264, Odds Ratio [OR], 95% confidence interval [CI] = 1.

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Social dominance is essential for maintaining a stable society and has both positive and negative impacts on social animals, including humans. However, the regulatory mechanisms governing social dominance, as well as the crucial regulators and biomarkers involved, remain poorly understood. We discover that mice lacking acid-sensing ion channel 2 (ASIC2) exhibit persistently higher social dominance than their wild-type cagemates.

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  • The study analyzed the effectiveness of the self-locking cage (ROI-C) compared to a conventional cage-plate (CCP) for treating spinal cord injuries without fractures or dislocations, reviewing 83 patients.
  • Results showed no significant differences in blood loss, improvement measures, or cervical lordosis between the two groups, but significant differences were found in disc height and T1 slope.
  • Ultimately, both methods achieved bony fusion, but ROI-C demonstrated stable fixation without cage migration at the final follow-up, highlighting its equivalent efficacy in cervical stability.
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CXCL13 is a chemokine that plays an important role in the regulation and development of secondary lymphoid organs. CXCL13 is also involved in the regulation of pathological processes, particularly inflammatory responses, of many diseases. The function of CXCL13 varies depending on the condition of the host.

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Introduction: The objective of this study was to assess the clinical characteristics and biometric parameters, as measured by the IOLMaster, of patients suffering from acute secondary angle closure due to zonular dialysis (ASAC-ZD) who were misdiagnosed with acute primary angle closure (APAC).

Methods: In this retrospective study, 34 ASAC-ZD and 39 APAC eyes were examined. Sex, age, best-corrected visual acuity, axial length (AL), anterior chamber depth (ACD), anterior chamber depth standard deviation (ACDSD), lens thickness (LT), and lens thickness standard deviation (LTSD) were measured using the IOLMaster and compared between the two groups.

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Synopsis of recent research by authors named "Hui Lu"

  • - Hui Lu's recent research explores the relationship between various health conditions, such as the causal link between type 2 diabetes and candidiasis, demonstrating significant genetic causation, as well as the impact of social dominance related to acid-sensing ion channels in mice.
  • - The studies also delve into specific medical interventions, including comparing surgical techniques for spinal cord injury treatment and utilizing oral propranolol for high-risk infantile hemangiomas, focusing on safety, efficacy, and long-term outcomes.
  • - Additionally, Lu investigates the molecular mechanisms underlying immune responses and neurodevelopmental disorders, highlighting the roles of chemokines and neurotransmitters in both cancer and social behavior, thus contributing to a broader understanding of physiological and therapeutic dynamics.