Achieving Robust Single-Photon Blockade with a Single Nanotip.

Backscattering losses (BSL), arising from intrinsic imperfections or unavoidable external perturbations in optical resonators, can severely impact photonic devices. In single-photon systems, robust quantum correlations against BSL remain largely unexplored despite their significance for various applications. Here, we demonstrate that single-photon blockade (SPB), a purely quantum effect, can be preserved against BSL by introducing a nanotip near a Kerr nonlinear resonator with intrinsic defects.

A facile liquid biopsy assay for highly efficient CTCs capture and reagent-less monitoring of immune checkpoint PD-L1 expression on CTCs with non-small cell lung cancer patients.

Programmed cell death 1 ligand 1 (PD-L1) immunotherapy holds a pivotal role in lung cancer treatment. However, current methods for monitoring PD-L1 expression exhibit several limitations, including hysteresis and the invasive nature of tissue sampling. Circulating tumor cells (CTCs), the important biomarkers in liquid biopsy, are minimally invasive and facilitate continuous monitoring.

Nonreciprocal single-photon band structure in a coupled-spinning-resonator chain.

We analyze the single-photon band structure and the transport of a single photon in a one-dimensional coupled-spinning-resonator chain. The time-reversal symmetry of the resonators chain is broken by the spinning of the resonators, instead of external or synthetic magnetic field. Two nonreciprocal single-photon band gaps can be obtained in the coupled-spinning-resonator chain, whose width depends on the angular velocity of the spinning resonator.

Magnetic-field-direction-controlled slow light and second-order sidebands in a cavity-magnon optomechanical system.

We theoretically study how the magnetic field direction controls both the transmission rate and the group delay of the signal, as well as the second-order sideband process in a hybrid cavity-magnon optomechanical system. By tuning the direction of the bias magnetic field, either a positive or negative magnon Kerr coefficient can be achieved, leading to a corresponding shift in the magnon frequency. As a result, the transmission rate can be significantly modified, resulting in a Fano-like transparency spectrum governed by the magnetic field direction, along with a slow-to-fast light switch also influenced by that direction.

Automated High-Throughput Affinity Capture-Mass Spectrometry Platform with Data-Independent Acquisition.

Affinity capture (AC) combined with mass spectrometry (MS)-based proteomics is highly utilized throughout the drug discovery pipeline to determine small-molecule target selectivity and engagement. However, the tedious sample preparation steps and time-consuming MS acquisition process have limited its use in a high-throughput format. Here, we report an automated workflow employing biotinylated probes and streptavidin magnetic beads for small-molecule target enrichment in the 96-well plate format, ending with direct sampling from EvoSep Solid Phase Extraction tips for liquid chromatography (LC)-tandem mass spectrometry (MS/MS) analysis.

Metasurface higher-order poincaré sphere polarization detection clock.

Accurately and swiftly characterizing the state of polarization (SoP) of complex structured light is crucial in the realms of classical and quantum optics. Conventional strategies for detecting SoP, which typically involves a sequence of cascaded optical elements, are bulky, complex, and run counter to miniaturization and integration. While metasurface-enabled polarimetry has emerged to overcome these limitations, its functionality predominantly remains confined to identifying SoP within the standard Poincaré sphere framework.

Observation of quantum strong Mpemba effect.

An ancient and counterintuitive phenomenon known as the Mpemba effect (water can cool faster when initially heated up) showcases the critical role of initial conditions in relaxation processes. How to realize and utilize this effect for speeding up relaxation is an important but challenging task in purely quantum system till now. Here, we experimentally study the strong Mpemba effect in a single trapped ion system in which an exponentially accelerated relaxation in time is observed by preparing an optimal quantum initial state with no excitation of the slowest decaying mode.

Smooth and safe stop: Fixed-time fault tolerant control for heavy legged robot with active identification on tolerance capability.

Heavy-legged robots (HLRs), integral to optimizing efficiency in manufacturing and transportation, rely on advanced active servo fault diagnosis and fault-tolerant control (FTC) mechanisms. This study presents an FTC framework with active fault status identification, fault tolerance capability assessment, and model uncertainty handling. A key contribution is the introduction of an active servo fault state estimator (ASFSE), which enables real-time monitoring of servo status by comparing residual differences between servo and controller outputs.

RNA-Seq Reveals the Mechanism of Pyroptosis Induced by Oxygen-Enriched IR780 Nanobubbles-Mediated Sono-Photodynamic Therapy.

Background: Sono-photodynamic therapy (SPDT), the combination of sonodynamic therapy (SDT) and photodynamic therapy (PDT), is a promising tumor treatment method. However, the hypoxic tumor microenvironment greatly compromises the efficacy of SPDT. Pyroptosis, a new type of programmed cell death, is mainly induced by some chemotherapeutic drugs in the current research, and rarely by SPDT.

Microwave quantum illumination: enhanced azimuth detection with cavity magnonics.

Most current microwave quantum illumination techniques rely on hybrid quantum systems to detect the presence of targets. However, real-world radar tasks are considerably more intricate than this simplistic model. Accurately determining physical attributes such as object speed, position, and azimuth is also essential.

The structural features and anti-inflammatory properties of a glucogalactan from Holotrichia diomphalia Bates (Qi Cao).

Ethnopharmacological Relevance: The dried larvae of Holotrichia diomphalia Bates, named Qi Cao, is a traditional Chinese medicine treat for liver diseases and arthritis. Polysaccharides is a principal component in Qi Cao, which exhibiting antioxidant and anti-inflammatory effects. However, the structural characteristics and underlying mechanisms of the polysaccharides remain inadequately elucidated.

Geographically weighted accelerated failure time model for spatial survival data: application to ovarian cancer survival data in New Jersey.

Background: In large multiregional cohort studies, survival data is often collected at small geographical levels (such as counties) and aggregated at larger levels, leading to correlated patterns that are associated with location. Traditional studies typically analyze such data globally or locally by region, often neglecting the spatial information inherent in the data, which can introduce bias in effect estimates and potentially reduce statistical power.

Method: We propose a Geographically Weighted Accelerated Failure Time Model for spatial survival data to investigate spatial heterogeneity.

TaNAR2.1 and TaNAR2.2 differ in influencing nitrogen uptake and growth of wheat (Triticum aestivum L.).

NAR2 (Nitrate assimilation related protein) is a protein chaperone involved in transporting nitrate across membranes. However, the expression pattern and function of NAR2 genes in wheat are still largely unknown. Here, we cloned two TaNAR2 genes (TaNAR2.

Nanobubble-mediated co-delivery of siTRIM37 and IR780 for gene and sonodynamic combination therapy against triple negative breast cancer.

Gene therapy often fails due to enzyme degradation and low transfection efficiency, and single gene therapy usually cannot completely kill tumor cells. Several studies have reported that tripartite motif-containing protein 37 (TRIM37) plays a significant role in promoting the occurrence and development of triple negative breast cancer (TNBC). Herein, we constructed siTRIM37 and IR780 co-loaded nanobubbles (NBs) to achieve the combination of gene therapy and sonodynamic therapy (SDT) against TNBC.

The clinical significance of pyogenic liver abscess after transarterial chemoembolization or microwave ablation on malignant liver tumors: A retrospective study.

Pyogenic liver abscess (PLA) is a rare but severe complication of interventional therapy that has been little studied. We aimed to find the risk factors for PLA after transarterial chemoembolization (TACE) or microwave ablation (MWA), further explore its clinical significance and summarize our experience with its treatment. Twenty-two patients with PLA and 118 randomly selected patients without PLA after TACE/MWA were enrolled.

Transcriptomic analysis reveals cross-talk genes between type 2 diabetes and recurrent benign paroxysmal positional vertigo.

Background: Benign paroxysmal positional vertigo (BPPV) is a common neurological disorder with a high recurrence rate. Type 2 diabetes mellitus (T2DM) is recognized as a risk factor for BPPV recurrence. However, the genomic association between T2DM and BPPV recurrence remains understudied.

Single-cavity loss-enabled nanometrology.

Optical monitoring of the position and alignment of objects with a precision of only a few nanometres is key in applications such as smart manufacturing and force sensing. Traditional optical nanometrology requires precise nanostructure fabrication, multibeam interference or complex postprocessing algorithms, sometimes hampering wider adoption of this technology. Here we show a simplified, yet robust, approach to achieve nanometric metrology down to 2 nm resolution that eliminates the need for any reference signal for interferometric measurements.

Multiomic analysis of monocyte-derived alveolar macrophages in idiopathic pulmonary fibrosis.

Background: Monocyte-derived alveolar macrophages (Mo_AMs) are increasingly recognised as potential pathogenic factors for idiopathic pulmonary fibrosis (IPF). While scRNAseq analysis has proven valuable in the transcriptome profiling of Mo_AMs, the integration analysis of multi-omics may provide additional dimensions of understanding of these cellular populations.

Methods: We performed multi-omics analysis on 116 scRNAseq, 119 bulkseq and five scATACseq lung tissue samples from IPF.