Dose-volume thresholds and smoking status for the risk of treatment-related pneumonitis in inoperable non-small cell lung cancer treated with definitive radiotherapy.

Purpose: To identify clinical risk factors and dose-volume thresholds for treatment-related pneumonitis (TRP) in patients with non-small cell lung cancer (NSCLC).

Methods And Materials: Data were retrospectively collected from patients with inoperable NSCLC treated with radiotherapy with or without chemotherapy. TRP was graded according to Common Terminology Criteria for Adverse Events, version 3.

A basic step toward understanding skin surface temperature distributions caused by internal heat sources.

This study uses numerical solutions of a bio-heat transfer equation to investigate the relationship between skin surface temperature distributions and internal heat sources under various physiological and environmental conditions. It is found that although a surface temperature distribution depends on all heat source parameters, the properly normalized distribution is primarily affected only by the depth of the heat source. This study provides a physical basis for determining the depth and type of an internal heat source from a thermogram acquired in various environmental conditions and an understanding of the basic relationship between skin surface temperature distributions and internal heat sources.