Distance-construal relationship: Mediating role of perceived control and moderating role of locus of control.

The construal level theory (CLT) has been supported and applied widely in social psychology. Yet, what remains unclear is the mechanism behind it. The authors extend the current literature by hypothesizing that perceived control mediates and locus of control (LOC) moderates the effect of psychological distance on the construal level.

Discovery of novel hydroxyamidine based indoleamine 2,3-dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1) dual inhibitors.

In order to take advantage of both immunotherapeutic and metabolic antitumor agents, novel dual indoleamine 2,3- dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1) inhibitors were designed. Thioredoxin reductase 1 (TrxR1) is a main ROS modulator within CRC cells. Indoleamine 2,3-dioxygenase (IDO1) is crucial controller for tryptophan (Trp) metabolism that is also important for CRC immunotherapy.