Publications by authors named "Hugo Kooiman"
Article Synopsis
- Two-photon microscopy (2PM) is a key technique in biology for examining intact tissues, but imaging depth is usually restricted to 600-800 μm due to scattering in adult mammalian tissues like mouse brains.
- * Researchers aimed to enhance imaging depth by utilizing shortwave near-infrared (SWIR) light, which has faced challenges due to the lack of suitable detectors and probes.
- * This study introduces a new array of superconducting nanowire single-photon detectors (SNSPDs) that, combined with specific fluorescent dyes, enables imaging depths greater than 1.1 mm in mouse brains, representing a significant advancement in deep tissue imaging technology.
This report highlights the combination of the MicroTime 100 upright confocal fluorescence lifetime microscope with a Single Quantum Eos Superconducting Nanowire Single-Photon Detector (SNSPD) system as a powerful tool for photophysical research and applications. We focus on an application in materials science, photoluminescence imaging, and lifetime characterization of Cu(InGa)Se (CIGS) devices intended for solar cells. We demonstrate improved sensitivity, signal-to-noise ratio, and time-resolution in combination with confocal spatial resolution in the near-infrared (NIR) range, specifically in the 1000-1300 nm range.
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