Publications by authors named "Hugo Francart"
Objectives: The objective of this study was to evaluate in a multicentre survey the analytical performance of the Check-Direct CPE® assay (CDCPE), a multiplex PCR assay for the detection of carbapenemase-producing Enterobacteriaceae (CPE), directly from rectal swabs.
Methods: Adult patients admitted to a high-risk unit in four participating centres were prospectively screened for CPE carriage by rectal swabbing. Samples were cultured on chromogenic CPE-selective media in the local laboratories.
Characterisation of a collection of Streptococcus pneumoniae isolates from patients suffering from acute exacerbations of chronic bronchitis: in vitro susceptibility to antibiotics and biofilm formation in relation to antibiotic efflux and serotypes/serogroups.
Nathalie M Vandevelde Paul M Tulkens Yvan Diaz Iglesias Jan Verhaegen Hector Rodriguez-Villalobos Hugo Francart
Int J Antimicrob Agents
September 2014
Article Synopsis
- The study investigates the relationship between Streptococcus pneumoniae serotypes, biofilm production, and antibiotic resistance in patients with acute exacerbations of chronic bronchitis.
- Most isolates came from older patients with frequent comorbidities, and biofilm-producing serogroups were prevalent, particularly those known for chronic infections.
- Results indicate significant antibiotic resistance, especially to macrolides, but no correlation was found between biofilm production and antibiotic susceptibility, suggesting serotyping could help guide treatment choices.