Publications by authors named "Hugo Alexandre Siqueira Guberovich Olivieri"
The GA-Hecate Peptide inhibits the ZIKV Replicative Cycle in Different Steps and can Inhibit the Flavivirus NS2B-NS3 Protease after Cell Infection.
Paulo Ricardo da Silva Sanches João Caldana Elias de Campos Faria Cíntia Bittar Hugo Alexandre Siqueira Guberovich Olivieri Nathalya Cristina de Moraes Roso Mesquita
Protein Pept Lett
October 2024
Background: Peptide drugs are advantageous because they are subject to rational design and exhibit highly diverse structures and broad biological activities. The NS2B-NS3 protein is a particularly promising flavivirus therapeutic target, with extensive research on the development of inhibitors as therapeutic candidates, and was used as a model in this work to determine the mechanism by which GA-Hecate inhibits ZIKV replication.
Objective: The present study aimed to evaluate the potential of GA-Hecate, a new antiviral developed by our group, against the Brazilian Zika virus and to evaluate the mechanism of action of this compound on the flavivirus NS2B-NS3 protein.