Publications by authors named "Hugh Jeffrey Lawrence"
Article Synopsis
- The study focused on evaluating gene expression in normal-looking tissues next to prostate tumors to see if it could help predict clinical recurrence of cancer after surgery.
- Researchers identified 46 genes linked to recurrence, many of which also corresponded to expressions in tumor tissue, indicating that both tissue types may share relevant biological markers.
- The findings, particularly involving the Genomic Prostate Score (GPS), suggest that gene expression patterns in adjacent non-tumor tissue can signal aggressive prostate cancer, highlighting a significant "field effect" influencing the disease's outcome.
The HOXA9 homeoprotein exerts dramatic effects in hematopoiesis. Enforced expression of HOXA9 enhances proliferation of primitive blood cells, expands hematopoietic stem cells (HSCs), and leads to myeloid leukemia. Conversely, loss of HOXA9 inhibits proliferation and impairs HSC function.
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