Publications by authors named "Hugh Flores"
Article Synopsis
- Researchers tested the antioxidant C3 on monkeys to see if it could improve nerve function after exposure to a neurotoxin related to Parkinson's disease.
- The study involved 15 macaque monkeys, with 8 receiving C3 and 7 receiving a placebo, focusing on various measures of motor function and brain activity over two months.
- Results showed that C3 significantly improved motor function and dopamine levels in the brain without any toxicity, indicating its potential as a treatment for Parkinson's disease.
Objective: Development of an effective therapy to slow the inexorable progression of Parkinson disease requires a reliable, objective measurement of disease severity. In the present study, we compare presynaptic positron emission tomography (PET) tracer uptake in the substantia nigra (SN) to cell loss and motor impairment in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated nonhuman primates.
Methods: Presynaptic PET tracers 6-[(18)F]-fluorodopa (FD), [(11)C]-2β-methoxy-3β-4-fluorophenyltropane (CFT), and [(11)C]-dihydrotetrabenazine (DTBZ) were used to measure specific uptake in the SN and striatum before and after a variable dose of MPTP in nonhuman primates.