Functional and anatomic consequences of subretinal dosing in the cynomolgus macaque.

Objective: To characterize functional and anatomic sequelae of a bleb induced by subretinal injection.

Methods: Subretinal injections (100 μL) of balanced salt solution were placed in the superotemporal macula of 1 eye in 3 cynomolgus macaques. Fellow eyes received intravitreal injections (100 μL) of balanced salt solution.

Brightness, contrast, and color balance of digital versus film retinal images in the age-related eye disease study 2.

Purpose: To analyze brightness, contrast, and color balance of digital versus film retinal images in a multicenter clinical trial, to propose a model image from exemplars, and to optimize both image types for evaluation of age-related macular degeneration (AMD).

Methods: The Age-Related Eye Disease Study 2 (AREDS2) is enrolling subjects from 90 clinics, with three quarters of them using digital and one quarter using film cameras. Image brightness (B), contrast (C), and color balance (CB) were measured with three-color luminance histograms.