Simulations to derive membrane resistivity in three phenotypes of guinea pig sympathetic postganglionic neuron.

The electrotonic behavior of three phenotypes of sympathetic postganglionic neuron has been analyzed to assess whether their distinct cell input capacitances simply reflect differences in morphology. Because the distribution of membrane properties over the soma and dendrites is unknown, compartmental models incorporating cell morphology were used to simulate hyperpolarizing responses to small current steps. Neurons were classified as phasic (Ph), tonic (T), or long-afterhyperpolarizing (LAH) by their discharge pattern to threshold depolarizing current steps and filled with biocytin to determine their morphology.