Publications by authors named "Hugh C Seton"

Object: To design and evaluate a fully shielded, λ/4 stripline resonator as a receive-only surface coil for preclinical MRI at 4.7 T.

Materials And Methods: A 20 mm diameter stripline surface coil was fabricated from double-sided Duroid 5880 PCB material and was directly coupled to the input of a MOSFET preamplifier, without requiring a matching network.

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Neural stem cells (NSCs) exhibit features that make them suitable candidates for stem cell replacement therapy and spinal cord reconstruction. Magnetic resonance imaging (MRI) offers the potential to track cells in vivo using innovative approaches to cell labeling and image acquisition. In this study, experiments were carried out to optimize the loading condition of magnetic CoPt hollow nanoparticles (CoPt NPs) into neural stem cells and to define appropriate MRI parameters.

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We have investigated the design and construction of liquid nitrogen cooled surface coils made from stranded (litz) copper wire for low field MRI applications. If designed correctly, cooled litz coils can provide a competitive alternative to high temperature superconducting (HTS) coils without the complications associated with flux trapping. Litz coils can also be produced with a wider range of shapes and sizes, and at lower cost.

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Two quantitative methods were developed for investigation of the potential of MRI for in vivo monitoring of retinal damage and detachment in experimental autoimmune uveitis (EAU). Measurements of retinal thickness and detachment area were performed on matched MR and histologic (HIST) images of rat eyes at different stages of EAU. In vivo MR images of rat eyes were acquired at 4.

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