Spatial omics-based machine learning algorithms for the early detection of hepatocellular carcinoma.

Background: Worldwide, hepatocellular carcinoma (HCC) is the second most lethal cancer, although early-stage HCC is amenable to curative treatment and can facilitate long-term survival. Early detection has proved difficult, as proteomics, transcriptomics, and genomics have been unable to discover suitable biomarkers.

Methods: To find new biomarkers of HCC, we utilized a spatial omics N-glycan imaging method to identify altered glycosylation in cancer tissue (n = 53) and in paired serum of individuals with HCC (n = 23).

Anterior cable reconstruction using subpectoral biceps tenodesis with biceps transfer in rotator cuff tears: a surgical technique.

Massive rotator cuff tears constitute approximately 20% of all rotator cuff tears. Poor tissue quality or significant retraction can lead to failure of the repair. The anterior rotator cuff cable is essential in transmitting force to the proximal humerus and serves as the main load-bearing structure within the supraspinatus.

Trends in Epidemiology and Treatment of Humerus Fractures in the United States, 2017-2022.

Background Fractures of the humerus are one of the more common fractures in the United States and a cause of fragility fractures in the elderly population. This study aims to understand recent trends in the demographic factors correlated with humeral shaft fractures (HSF) and humeral shaft fracture nonunion (HSFN) following open reduction internal fixation (ORIF) and intramedullary nailing (IMN). Methods The TriNetX database was used to query using International Classification of Diseases-10 (ICD10) diagnosis codes for patients who sustained HSF between 2017 and 2022.

Primary Open Latarjet Procedure Versus Revision to Open Latarjet Procedure for Anterior Shoulder Instability.

Background: Although the Latarjet operation may be performed as a revision surgery for anterior shoulder instability, the high recurrence rate of anterior shoulder instability after arthroscopic Bankart repair (ABR) has led some to advocate for performing the Latarjet procedure as a primary stabilization surgery. The purpose of this study was to compare the intermediate-term outcomes after primary open Latarjet (PLJ) and revision to open Latarjet (RLJ).

Materials And Methods: This was a single-institution retrospective analysis of patients who underwent either PLJ or RLJ procedures for anterior shoulder instability between 2014 and 2023.

Similar return to sport between double cortical button and docking techniques for ulnar collateral ligament reconstruction in baseball players.

Background And Hypothesis: A double cortical button technique for ulnar collateral ligament reconstruction (UCLR) has advantages including significant control over graft tensioning, less concern about graft length, and minimized risk of bone tunnel fracture compared with traditional UCLR techniques. This double cortical button technique was recently found to be noninferior in mechanical performance to the traditional docking technique regarding joint strength, joint stiffness, and graft strain. However, clinical outcomes have not been compared between these UCLR techniques.

Similar Biomechanics Between the Double-Cortical Button and Docking Techniques for Ulnar Collateral Ligament Reconstruction: A Cadaveric Evaluation.

Background: The docking technique is widely used to perform ulnar collateral ligament (UCL) reconstructions because of its high failure torque and reliable clinical outcomes. A double-cortical button technique was recently described, with advantages including the ability to tension the graft at the ulnar and humeral attachments and the creation of single bone tunnels.

Purpose/hypothesis: To compare the biomechanics between the docking and double-button UCL reconstruction techniques using cadaveric specimens.

Interactions among endogenous, exogenous, and agency-driven attentional selection mechanisms in interactive displays.

Attentional selection is driven, in part, by a complex interplay between endogenous and exogenous cues. Recently, one's interactions with the physical world have also been shown to bias attention. Specifically, the sense of agency that arises when our actions cause predictable outcomes biases our attention toward those things which we control.

Conjoint tendon lengthening for recalcitrant anterior shoulder pain after reverse shoulder arthroplasty: a technique article.

The incidence of reverse shoulder arthroplasty (RSA) has increased since the Food and Drug Administration approved its use in the United States in 2004. With the current RSA implants available for surgeon use within the United States of America, each design, regardless of humeral inlay vs. onlay, distalizes the shoulder's center of rotation.

The human cognitive system corrects traces of error commission on the fly.

Human perception and action rely on a fundamental binding mechanism that forges integrated event representations from distributed features. Encountering any one of these features later on can retrieve the whole event, thus expediting cognitive processing. The traditional view on binding confines it to successful action episodes, holding that the human cognitive system does not leverage errors for optimizing corresponding event representations.

Evaluating whole-genome expression differences in idiopathic and diabetic adhesive capsulitis.

Background: Diabetic patients have a greater incidence of adhesive capsulitis (AC) and a more protracted disease course than patients with idiopathic AC. The purpose of this study was to compare gene expression differences between AC with diabetes mellitus and AC without diabetes mellitus.

Methods: Shoulder capsule samples were prospectively obtained from diabetic or nondiabetic patients who presented with shoulder dysfunction and underwent arthroscopy (N = 16).

Risk factors associated with atraumatic posterolateral rotatory instability.

Background: Traumatic posterolateral rotatory instability after elbow dislocation or fracture dislocation has been well described. However, few reports cover atraumatic posterolateral rotatory instability as a cause of lateral-sided elbow pain. We assessed the risk factors and epidemiology of atraumatic posterolateral rotatory instability in a case-control study.

Perception during use of force and the likelihood of firing upon an unarmed person.

Stress can impact perception, especially during use-of-force. Research efforts can thus advance both theory and practice by examining how perception during use-of-force might drive behavior. The current study explored the relationship between perceptual judgments and performance during novel close-combat training.

Does task-irrelevant music affect gaze allocation during real-world scene viewing?

Gaze control manifests from a dynamic integration of visual and auditory information, with sound providing important cues for how a viewer should behave. Some past research suggests that music, even if entirely irrelevant to the current task demands, may also sway the timing and frequency of fixations. The current work sought to further assess this idea as well as investigate whether task-irrelevant music could also impact how gaze is spatially allocated.

Preoperative tendon retraction, not smoking, is a risk factor for failure with continuity after rotator cuff repair.

Background: Smoking is a poor prognostic factor for healing after rotator cuff repair and is associated with inferior results. We hypothesized that smokers would have higher recurrent tear rates and more postoperative myotendinous junction (MTJ) retraction in healed repairs than nonsmokers three months postoperatively.

Methods: Rotator cuff repairs (RCRs) were retrospectively reviewed over a 2-year period.

Where the eyes wander: The relationship between mind wandering and fixation allocation to visually salient and semantically informative static scene content.

Vision is crucial for many everyday activities, but the mind is not always focused on what the eyes see. Mind wandering occurs frequently and is associated with attenuated visual and cognitive processing of external information. Corresponding changes in gaze behavior-namely, fewer, longer, and more dispersed fixations-suggest a shift in how the visual system samples external information.

PPDIST, global 0.1° daily and 3-hourly precipitation probability distribution climatologies for 1979-2018.

We introduce the Precipitation Probability DISTribution (PPDIST) dataset, a collection of global high-resolution (0.1°) observation-based climatologies (1979-2018) of the occurrence and peak intensity of precipitation (P) at daily and 3-hourly time-scales. The climatologies were produced using neural networks trained with daily P observations from 93,138 gauges and hourly P observations (resampled to 3-hourly) from 11,881 gauges worldwide.

Metastatic Lung Cancer Presenting as Monocular Blindness and Panhypopituitarism Secondary to a Pituitary Metastasis.

BACKGROUND Sellar masses are most commonly pituitary adenomas, however, about 1% of surgical resected pituitary lesions are found to be metastatic disease. It is hard to distinguish pituitary adenomas from metastatic disease. The most common primary sources for pituitary metastases are breast and lung cancer.

Attentional selection is biased towards controllable stimuli.

While the factors that contribute to individuals feeling a sense agency over a stimulus have been extensively studied, the cognitive effects of a sense of agency over a stimulus are little known. Here, we conducted three experiments examining whether attentional selection is biased towards controllable stimuli. In all three experiments, participants moved four circle stimuli, one of which was under their control.