Publications by authors named "Hufan Li"
Article Synopsis
- The research investigates the gut microbial composition in patients with gouty arthritis (GA) compared to healthy controls, focusing on bacteria, fungi, and viruses present.
- Significant changes were found, with 1,117 bacterial species, 23 fungal species, and 4,115 viral operational taxonomic units being differentially abundant in GA patients.
- The identified microbial signatures show potential for diagnostic purposes, aiding in distinguishing between GA patients and healthy individuals, while highlighting the complex interactions among various microbial communities.
Objective: Sjögren's syndrome (SS) is an inflammatory autoimmune disease characterized by high levels of chronic lymphocyte infiltration. Differences and dysfunction in the gut microbiota and metabolites may be closely related to the pathogenesis of SS. The purpose of this study was to reveal the relationship between the gut microbiota and metabolome in NOD mice as a model of SS and the role of FuFang Runzaoling (FRZ), which is a clinically effective in treating SS.
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- Researchers studied the gut viral community in 16 patients with systemic lupus erythematosus (SLE) and 31 healthy individuals, using advanced sequencing methods to uncover differences in virome composition.
- SLE patients showed a notable decrease in gut viral diversity and significant changes in viral family composition compared to healthy controls, with specific viral types enriched in either group.
- The study suggests that gut virome alterations could potentially serve as a predictive tool for SLE, achieving a high accuracy in distinguishing between patients and healthy individuals.
The gut microbiota plays an essential role in the regulation of the immune system and the etiology of human autoimmune diseases. However, a holistic understanding of the gut bacteriome, mycobiome, and virome in patients with osteoarthritis (OA) remains lacking. Here, we explored the gut microbiotas of 44 OA patients and 46 healthy volunteers via deep whole-metagenome shotgun sequencing of their fecal samples.
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