Publications by authors named "Huei-Shan Lin"
Background/aim: The role of postoperative radiotherapy (RT) combined with chemotherapy (CT) for lymph node-positive (LN+) triple-negative breast cancer (TNBC) remains controversial. SUV39H1-mediated epigenetic regulation is associated with cancer cell migration, invasion, metastasis, and treatment resistance. This study aims to identify the role of SUV39H1 in TNBCs.
View Article and Find Full Text PDFEndocrine therapy (ET) of selective estrogen receptor modulators (SERMs), selective estrogen receptor downregulators (SERDs), and aromatase inhibitors (AIs) has been used as the gold standard treatment for hormone-receptor-positive (HR+) breast cancer. Despite its clinical benefits, approximately 30% of patients develop ET resistance, which remains a major clinical challenge in patients with HR+ breast cancer. The mechanisms of ET resistance mainly focus on mutations in the ER and related pathways; however, other targets still exist from ligand-independent ER reactivation.
View Article and Find Full Text PDFArticle Synopsis
- A seroepidemiological survey in the Republic of the Marshall Islands examined Toxoplasma gondii infection in primary school children, revealing an overall infection rate of 54.8%.
- Significant differences in infection rates were noted between genders and age groups, with younger children more likely to have high LA titers, indicating stronger infections.
- Urban living increased the risk of infection, while factors like raw meat consumption, drinking unboiled water, and cat cleaning habits showed no correlation; this study is a crucial first step in understanding and controlling T. gondii transmission in the area.
Background: Toxocariasis, which is predominantly caused by Toxocara canis (T. canis) infection, is a common zoonotic parasitosis worldwide; however, the status of toxocariasis endemicity in the Republic of the Marshall Islands (RMI) remains unknown.
Methods: A seroepidemiological investigation was conducted among 166 primary school children (PSC) aged 7-12 years from the capital area of the RMI.