[Effect of tetramethylpyrazine on Nogo gene regulation of the proliferation in cardiac fibroblast].

Objective: To investigate the effects of different doses of Tetramethylpyrazine (TMP) on collagen synthesis and Nogo expression in cardiac fibroblasts and the potential role of Nogo in myocardial fibrosis.

Methods: The cultured neonatal rat cardiac fibroblasts were induced by angiotensin II and TMP at the same time. The mRNA expression of Nogo-A, Nogo-B and collagen I were detected with real-time fluorescence quantitative PCR.