Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial.

Importance: Sepsis screening is recommended among hospitalized patients but is supported by limited evidence of effectiveness.

Objective: To evaluate the effect of electronic sepsis screening, compared with no screening, on mortality among hospitalized ward patients.

Design, Setting, And Participants: In a stepped-wedge, cluster randomized trial at 5 hospitals in Saudi Arabia, 45 wards (clusters) were randomized into 9 sequences, 5 wards each, to have sepsis screening implemented at 2-month periods.

Synthesis and Biological Evaluation of Novel Imidazole Derivatives as Antimicrobial Agents.

Imidazole derivatives are considered potential chemical compounds that could be therapeutically effective against several harmful pathogenic microbes. The chemical structure of imidazole, with a five-membered heterocycle, three carbon atoms, and two double bonds, tends to show antibacterial activities. In the present study, novel imidazole derivatives were designed and synthesized to be evaluated as antimicrobial agents owing to the low number of attempts to discover new antimicrobial agents and the emerging cases of antimicrobial resistance.

Synthesis of Silver(I) Complexes Containing 3-Oxo-3-phenyl-2-(2-phenylhydrazono)propanal-Based Ligands as a Multifunction Platform for Antimicrobial and Optoelectronic Applications.

Toward multifunctionality, including antimicrobial and optoelectronic applications, herein, we reported the synthesis of a novel Ag(I) complex with 3-oxo-3-phenyl-2-(2-phenylhydrazono)propanal-based ligands including 3-(4-chlorophenyl)-2-[2-(4-nitrophenyl)hydrazono]-3-oxopropanal (named as ""), 3-(4-chlorophenyl)-2-[2-(4-methylphenyl)hydrazono]-3-oxopropanal (named as ""), and 3-(4-chlorophenyl)-3-oxo-2-(2-phenylhydrazono)propanal (named as ""). The synthesized compounds were characterized through FTIR, H NMR, and density functional theory (DFT). The morphological features and thermal stability were evaluated through transmission electron microscopy (TEM) and TG/DTA analysis.

Synthesis and characterization of phenothiazine sensor for spectrophotometric and fluorescence detection of cyanide.

A sensitive and selective phenothiazine-based sensor (PTZ) has been successfully synthesized. The sensor PTZ displayed specific identification of CN 'turn-off' fluorescence responses with a quick reaction and strong reversibility in an acetonitrile:water (90:10, V/V) solution. The sensor PTZ for detecting CN exhibits the marked advantages of quenching the fluorescence intensity, fast response time (60 s), and low value of the detection limit.

Green Synthesis and Antibacterial Activity of Ag/FeO Nanocomposite Using Extract.

In the study reported in this manuscript, silver/iron oxide nanocomposites (Ag/FeO) were phytosynthesized using the extract of via a green, economical and eco-friendly strategy. The biosynthesized Ag/FeO nanocomposites were characterized using UV-Vis spectrophotometry, FTIR, XRD, TEM, DLS and SEM-EDX analyses. The particulates showed a triangular and spherical morphology having sizes between 25 and 174 nm.

Statistical analysis plan for the Steppedwedge Cluster Randomized trial of Electronic Early Notification of sepsis in hospitalized ward patients (SCREEN).

Background: It is unclear whether screening for sepsis using an electronic alert in hospitalized ward patients improves outcomes. The objective of the Stepped-wedge Cluster Randomized Trial of Electronic Early Notification of Sepsis in Hospitalized Ward Patients (SCREEN) trial is to evaluate whether an electronic screening for sepsis compared to no screening among hospitalized ward patients reduces all-cause 90-day in-hospital mortality.

Methods And Design: This study is designed as a stepped-wedge cluster randomized trial in which the unit of randomization or cluster is the hospital ward.

Electronic early notification of sepsis in hospitalized ward patients: a study protocol for a stepped-wedge cluster randomized controlled trial.

Background: To evaluate the effect of screening for sepsis using an electronic sepsis alert vs. no alert in hospitalized ward patients on 90-day in-hospital mortality.

Methods: The SCREEN trial is designed as a stepped-wedge cluster randomized controlled trial.

Aloe vera extract: A novel antimicrobial and antibiofilm against methicillin resistant Staphylococcus aureus strains.

Bacterial infectious maladies are the leading cause of death worldwide. Microbial drug resistance boosts the severity of the maladies. In the present study, the antibacterial impact of Aloe vera leaf aqueous extract against six strains of methicillin resistant Staphylococcus aureus (LN872136, LN872137, LN871238, LN871239, LN872140, LN871241) was investigated in vitro.

Vagal Nerve Stimulation (VNS) Therapy System Implementation at a Neurology Department in Saudi Arabia.

The objective of this paper is to report on the implementation of a Vagal Nerve Stimulation (VNS) Therapy System at a neurology department in Saudi Arabia. Key informant interviews, meeting documents, and experience of the researcher were part of the data collection sources used in the study. A thematic analysis of the data was conducted.

Remote Patient Monitoring System Implementation at a Cardiac Care Centre in Saudi Arabia.

The objective of this paper is to report the implementation experiences of a remote patient monitoring system at a cardiac care center in Saudi Arabia. Key informant interviews, meeting documents, and experience of the researcher were part of the data collection sources used in the study. A thematic analysis of the data was conducted.

The Implementation Experiences of an Endoscopy Information System (EIS) on the Improvement of Workflow Processes in a Saudi Endoscopy Department.

The objective of this paper is to investigate the experiences in implementing a smart capsule system for a Saudi endoscopy department. The study was conducted at a leading Saudi healthcare institution located in Riyadh, Saudi Arabia. A case study approach was used in the study.