Recombinant () Vaccine Candidate Expressing Avian Pathogenic Type I Fimbriae Provides Protections against APEC O78 and O161 Serogroups and Infection.

Avian pathogenic (APEC) is one of the leading pathogens that cause devastating economic losses to the poultry industry. Type I fimbriae are essential adhesion factors of APEC, which can be targeted and developed as a vaccine candidate against multiple APEC serogroups due to their excellent immunogenicity and high homology. In this study, the recombinant strain SG102 was developed by expressing the APEC type I fimbriae gene cluster () on the cell surface of an avirulent () vector strain using a chromosome-plasmid-balanced lethal system.

Melatonin Is Neuroprotective in Meningitis Depending on Intestinal Microbiota.

Avian meningitis () can cause acute bacterial meningitis which threatens poultry health, causes great economic losses in the poultry industry, and has recently been speculated as a potential zoonotic pathogen. Melatonin can counteract bacterial meningitis-induced disruption of the blood-brain barrier (BBB), neuroinflammation, and reduce mortality. There are increasing data showing that melatonin's beneficial effects on bacterial meningitis are associated with intestinal microbiota.

Safety and protective effects of an avirulent Salmonella Gallinarum isolate as a vaccine candidate against Salmonella Gallinarum infections in young chickens.

Fowl typhoid is an important disease of chickens and turkeys, which is caused by Salmonella Gallinarum (S. Gallinarum). Vaccines with high levels of protective effects against fowl typhoid need to be developed for the poultry industry.

Therapeutic Opportunities in Colorectal Cancer: Focus on Melatonin Antioncogenic Action.

Colorectal cancer (CRC) influences individual health worldwide with high morbidity and mortality. Melatonin, which shows multiple physiological functions (e.g.

Intestinal microbiota mediates Enterotoxigenic Escherichia coli-induced diarrhea in piglets.

Background: Enterotoxigenic Escherichia coli (ETEC) causes diarrhea in humans, cows, and pigs. The gut microbiota underlies pathology of several infectious diseases yet the role of the gut microbiota in the pathogenesis of ETEC-induced diarrhea is unknown.

Results: By using an ETEC induced diarrheal model in piglet, we profiled the jejunal and fecal microbiota using metagenomics and 16S rRNA sequencing.

Jejunal Metabolic Responses to Infection in Piglets.

This study aimed to investigate the jejunal metabolic variations in enterotoxigenic (ETEC)-infected piglets. Piglets were infected with 1 × 10 CFUs (colony-forming units) of ETEC W25K and assigned into diarrheal, recovered, control, and resistant groups. Jejunal samples were harvested at day 6 and metabolic profiles were analyzed via gas chromatography coupled to time-of-flight mass spectrometry (GC/TOFMS).