Economic impact of simplified de Gramont regimen in first-line therapy in metastatic colorectal cancer.

The cost of chemotherapy has dramatically increased in advanced colorectal cancer patients, and the schedule of fluorouracil administration appears to be a determining factor. This retrospective study compared direct medical costs related to two different de Gramont schedules (standard vs. simplified) given in first-line chemotherapy with oxaliplatin or irinotecan.

Gastrointestinal and biliopancreatic response to continuous nasogastric feeding in man: effect of increasing nutrient infusion rate.

Nasogastric feeding is a safe and inexpensive procedure used in various conditions to provide artificial nutritional support. However, the effects of increasing energy load of nutrients during continuous enteral nutrition on gastric physiology, biliopancreatic secretions and intestinal absorption of nutrients are unknown. A nutrient solution (1 kcal/ml, 15% proteins, 30% lipids, 55% carbohydrates) was randomly infused at three rates, 1.

Inhibitory effect of jejunal high caloric nutrient load on human biliopancreatic secretion. The role of atropine, naloxone and composition of nutrient solutions.

Our previous studies shown that a high caloric load in the jejunum decreases biliopancreatic output. However, the factors responsible for this inhibition have not yet been fully assessed. In this study, we have compared the effect of a high caloric load of either proteins or carbohydrates on stimulated pancreatic output and investigated the mechanism of this inhibition.

Fate of orally ingested enzymes in pancreatic insufficiency: comparison of two pancreatic enzyme preparations.

The effect on steatorrhoea of a pH-sensitive enteric-coated pancreatic preparation (Eurobiol 25,000) was compared with a conventional pancreatic enzyme preparation (Eurobiol) in six adult patients with exocrine pancreatic insufficiency. In addition, the fate of orally ingested pancreatic enzymes in the upper digestive tract was evaluated by measuring gastric and duodenal pH, amount of enzymes in the stomach, duodenal enzyme output, and fat absorption at the angle of Treitz for the 4 hours following a standard meal. When compared with placebo, Eurobiol and Eurobiol 25,000 reduced daily faecal fat excretion by 24% (not significant) and 43% (P less than 0.

Human jejunal secretion induced by prostaglandin E1: a dose-response study.

1. Intraluminally infused prostaglandins induce jejunal secretion of water and electrolytes in man, and a receptor-mediated process in the intestinal epithelial cells has been suggested to explain this secretion. In an attempt to obtain data under basal conditions for pharmacological studies, we tested the dose-response effect of PGE1 on jejunal hydroelectrolytic movements in 10 healthy volunteers.

Effect of jejunal infusion of nutrients on gastrointestinal transit and hormonal response in man.

The effects of jejunal infusion of nutrients on gastric emptying and secretion, intestinal transit and hormone release were studied in human volunteers. Two caloric loads, 1.3 and 3.

Inhibitory effect of high caloric load of carbohydrates or lipids on human pancreatic secretions: a jejunal brake.

Effects of jejunal infusion of a saline solution, a protein meal, and a mixed protein and carbohydrate meal on biliopancreatic secretions were compared in six healthy volunteers. Protein infusion stimulated biliopancreatic secretions whereas carbohydrate infusion inhibited these secretions compared with saline infusion. The roles of lipid, carbohydrate, and caloric load on the inhibition of pancreatic secretions by jejunal infusion of nutrients was investigated in six other healthy volunteers.

Almitrine bismesylate disposition in the human digestive tract.

The absorption of almitrine from the upper gastrointestinal tract has been evaluated in 6 healthy volunteers by an intubation technique. Almitrine bismesylate dissolved in malic acid was introduced into the stomach after homogenization with a meal containing the marker 14C-polyethylene glycol (PEG) 4000. Unlabeled PEG 4000 was infused into the second part of duodenum throughout the experiment.

Metformin in the digestive tract.

After ingestion of metformin, a drug of the biguanide class, there are gastrointestinal effects in the form of nausea and vomiting, and about 30% of the drug is recovered in feces. The purpose of this work was to explain these two phenomena. Two sets of experiments were carried out.

Erosive arthritis of the costovertebral joint in seronegative spondyloarthropathy.

A 50-year-old male presented with polyarthritis and pain of the right costovertebral angle in the cervicothoracic area. Radiological findings in a sacroiliac joint, the presence of a syndesmophyte, the HLA B-27 phenotype and negative serological studies prompted the diagnosis of HLA-B27 related seronegative spondyloarthropathy. Conventional and computerized tomograms disclosed an erosive arthritis of the 1st right costovertebral joint that was responsible for the pain in the costovertebral angle.

[Influence of Saccharomyces boulardii on jejunal secretion in rats induced by cholera toxin].

The effects of a suspension of Saccharomyces boulardii cells on water and sodium secretion induced by cholera toxin was measured in male Wistar rats weighing 220-260 g, using the isolated jejunal loop technique. Concentrations per ml of 3.1 X 10(9), 2.

[Hemarthrosis of articular chondrocalcinosis. Apropos of 28 cases. Importance of treatment by isotopic synoviorthesis].

32 cases of hemarthrosis observed in 26 patients suffering from articular chondrocalcinosis are used as a basis for a review of the principal clinical anc paraclinical findings. Special mention is made of the fact that hemarthrosis occurs in the shoulder much less rarely than has been classically reported. The diagnostic value of finding microcristals of calcium pyrophosphate in hemorrhagic fluid is also emphasized.

[Cryptal origin of the intestinal secretion induced in rats by prostaglandin El. Evolution of secretion after a single injection of 5-fluorouracil].

The intestinal secretions induced by an intrajejunal perfusion of prostaglandin E1 (PGE1) at the rate of 24 gamma/min in anaesthetized male Wistar rats, weighing 200-200 g, were studied during 6 days after a single injection of an antimitotic agent, the 5-fluorouracil (5-FU, 40 mg/kg). 5-FU induced changes in the structure of the intestinal mucosa. The modifications observed in the intestinal secretions of water and sodium induced by PGE1 suggest that these secretions might (a) originate from crypts; (b) be partly reabsorbed by villi.

Hydroelectrolytic movements in rat jejunum during the alterations of the mucosa induced by a single injection of 5-fluorouracil.

Transmucosal movements of water and electrolytes were measured in male Wistar rats, using the intestinal perfusion technique after a single intramuscular injection of 40 mg/kg BW of 5-fluorouracil. These movements were studied, daily during 6 days after the injection, in relation to the histological study of mucosa. The results (1) may explain the diarrhoea observed in patients treated with this antimitotic agent; (2) suggest the existence of a secretion in crypts, followed by an incomplete reabsorption by villi; the secretion of crypts or the villus reabsorption are alternatively the driving factor depending on the reciprocal size of villi and crypts.

[Immunofluorescent deposits in normal rheumatoid skin].

Predominantly IgM immunofluorescent deposits have been found in 30% of normal, non exposed skin in a group of rheumatoid arthritis patients. Neither clinical nor biological correlation have been found. Because one case with cryoglobulinemia was positive, study of other non lupus, cryoglobulinemic, immune complexe type of diseases has been done.