[Prevention of pregnancy in bitches with the progesterone antagonist anglepristone (alizone)].

A study was carried out between April 1997 and October 1998 to determine the effect of the progesterone antagonist, Aglépristone (Alizine), for the prevention of pregnancy. 93 bitches were treated, because of mismating, with Aglépristone. The owners were then contacted 2 weeks and 6 to 12 months after treatment to gather any information on effects noted over this period.

Combination of balanced and regional anaesthesia for minimally invasive surgery in a patient with myasthenia gravis.

A 45-year-old man with cryptorchism, who was known to suffer from generalized myasthenia gravis, was admitted to hospital for surgical treatment using laparoscopy. Such minimally invasive surgery requires good muscle relaxation. However, the use of neuromuscular blocking agents in patients with myasthenia gravis may lead to prolonged apnoea after operation, thus necessitating mechanical ventilation of the lungs.

Sry-negative XX true hermaphrodite in a Basset hound.

A true hermaphrodite was diagnosed in a 7-mo.-old Basset hound. The diagnosis was based on the clinical signs, the histology of the gonads and the karyogram.

Medium-term results of heart transplantation using donors over 63 years of age.

Background: The continual shortage of hearts for transplantation (HTx) led to the expansion of the donor pool by accepting older donors. We compared the medium-term follow-up of patients after HTx with older hearts (over the age of 63 years) with those of patients after HTx with younger hearts.

Patients And Methods: Since April 1994 we have used hearts for HTx from donors older than the age of 63 years.

Validation of fluorescent-labeled microspheres for measurement of relative blood flow in severely injured lungs.

The aim of the study was to validate a nonradioactive method for relative blood flow measurements in severely injured lungs that avoids labor-intensive tissue processing. The use of fluorescent-labeled microspheres was compared with the standard radiolabeled-microsphere method. In seven sheep, lung injury was established by using oleic acid.

Vaporized perfluorocarbon improves oxygenation and pulmonary function in an ovine model of acute respiratory distress syndrome.

Background: Perfluorocarbon liquids are being used experimentally and in clinical trials for the treatment of acute lung injury. Their resemblance to inhaled anesthetic agents suggests the possibility of application by vaporization. The authors' aim was to develop the technical means for perfluorocarbon vaporization and to investigate its effects on gas exchange and lung function in an ovine model of oleic acid-induced lung injury.

Double-outlet right ventricle with non-committed ventricular septal defect.

Objective: The term non-committed was used to define hearts in which the VSD was anatomically related to, or was close to, neither great vessel, being separated from both by considerable muscle. We report our experience of the surgical management of this subset, considered being of particular surgical relevance.

Methods: Between January 1987 and December 1997, 23 patients having double-outlet right ventricle (DORV) with non-committed VSD underwent biventricular repair.

Inflammatory bowel disease in Saudi Arabia: presentation and initial management.

Non-specific Inflammatory Bowel disease (IBD) is infrequently seen in the Arabs of the Arabian Peninsula. This paper documents the presentation and initial management of 101 such Arabs treated for inflammatory bowel disease between 1976 and 1994. Medical records were examined and patients were classified according to the Organisation Mondiale de Gastroenterologie diagnostic scoring system.

Inflammatory bowel disease in Saudi Arabia - non-operative and operative management at King Faisal Specialist Hospital.

Full text is available as a scanned copy of the original print version.

The relationship between the mitral annulus and left ventricular outflow tract.

Mitral annular inflexibility due to rigid prostheses (ring or valve) has long been considered to contribute to the mechanism of dynamic left ventricular outflow tract (LVOT) obstruction after mitral repair or replacement. In clarifying the geometric relationship between LVOT orifice and mitral valve annulus (MVA) in eight normal subjects, the authors have endeavored to show how that a rigid mitral prosthesis might obstruct the LVOT based on the assumption that any rigid prosthesis necessarily follows the motion of the posterior half of the MVA (MVApost) in the course of every heart beat. During systole, the relationship between the MVApost and the approximated plane of the LVOT orifice was constant.

Dynamic change in the left ventricular base with or without a rigid mitral valve prosthesis.

To evaluate the narrowing of the left ventricular outflow tract (LVOT) during systole caused by a rigid mitral prosthesis, the geometric relationship between the prosthesis (or the mitral annulus) and the left ventricular base (LVB) was studied in five patients with mechanical mitral valve prostheses and eight normal subjects. The images of the mitral valve annulus (MVA) and the LVOT orifice reconstructed in three dimensions were projected on the plane of the LV base. Calculating the areas of these projected images (i.

Imaging of the orifice of the left ventricular outflow tract: technique and initial results.

The mechanism of left ventricular outflow tract (LVOT) obstruction in the patient after mitral valve replacement or repair was examined with the aid of 2D echocardiography. For the interpretation of the spatial relationship between the aortic root and mitral annulus, however, the 2D display is sometimes inadequate since it may not simultaneously capture these structures in each center. We developed a method to clarify this relationship in 3D based on magnetic resonance images.

Effect of intra-abdominally induced pressure on the urethral pressure profiles of healthy and incontinent bitches.

Objective: To determine whether reduced pressure transmission is of importance in the pathophysiologic mechanism of urinary incontinence in bitches.

Animals: 20 sexually intact, continent bitches and 21 spayed, incontinent bitches.

Procedure: Urethral pressure profiles before (resting) and after (stressed) insufflation of gas in the abdominal cavity were recorded in bitches under general anesthesia.

Mitral annular flexibility.

An analysis of three-dimensional movement of the mitral valve annulus (MVA) may address the question of geometrical change after mitral valve repair to preserve mitral annular function. Conventionally, annular contraction has been studied for this purpose. We investigated this geometrical change occurring in the anterior half of the MVA and discuss its clinical significance.

Surgical treatment of male dogs with urinary incontinence due to urethral sphincter mechanism incompetence.

A modified technique for fixation of the deferent ducts to the abdominal wall as a therapy for urinary incontinence caused by urethral sphincter mechanism incompetence (USMI) in male dogs is described, and the results in seven dogs are reported. The goal of this treatment was to achieve an effect similar to colposuspension in female dogs with USMI. An increase in urethral length of an average of 28 mm was obtained (range, 5 to 50 mm, measured radiographically).

The inflexible mitral annulus after valve prosthesis. Inherent risk of dynamic left ventricular outflow tract obstruction.

Although chordal preserving mitral valve replacement is beneficial to cardiac function, the loss of flexibility of the annulus and consequent translational motion of the valve prosthesis during systole may cause potential left ventricular outflow tract (LVOT) obstruction after surgery. The extent of the flexibility of the mitral valve annulus (MVA) necessary for the prosthetic valve to prevent potential LVOT obstruction was determined. The three dimensional images of the MVA at 0, 100, 200, and 300 msec delay from the electrocardiogram R wave were reconstructed from cine-mode magnetic resonance images in eight normal subjects.

Mucolipidosis type II in a domestic shorthair cat.

A seven-month-old, female domestic shorthair cat was presented to the Veterinary Teaching Hospital, University of Zurich, with abnormal facial features, retarded growth and progressive hindlimb paresis. On physical examination the cat had a flat, broad face with hypertelorism, frontal bossing, small ears and thickened upper and lower eyelids. The corneas of both eyes were clear and the pupils were dilated.

Metabolic effects of trifluoperazine in the liver and the influence of calcium.

The effects of trifluoperazine on hepatic cell metabolism were investigated using isolated perfused rat liver. The following effects of trifluoperazine were found: (1) trifluoperazine inhibited oxygen uptake, the site of action being the mitochondria. Half-maximal inhibition occurred at concentrations around 50 microM; with 100 microM trifluoperazine the effect was already maximal.

Uterine serosal inclusion cysts in a bitch.

A six-year-old, pluriparous German shepherd dog bitch was presented with an abnormal vaginal discharge of several weeks' duration. Clinical signs and radiographic and ultrasonographic findings supported an initial diagnosis of segmental cystic endometrial hyperplasia, and ovariohysterectomy was performed. Macroscopically, the uterus appeared normal except for one large and several smaller cysts attached to its antimesometrial side.

Treatment of urinary incontinence in bitches by endoscopic injection of glutaraldehyde cross-linked collagen.

Thirty-two spayed bitches with urinary incontinence due to urethral sphincter incompetence, non-responsive to phenylpropanolamine administration, were treated by urethral submucosal injection of glutaraldehyde cross-linked collagen. Urinary incontinence resolved after a single injection in 19 of the bitches. Additional medication with phenylpropanolamine was necessary in five of these dogs, however.

Spontaneous mucolipidosis in a cat: an animal model of human I-cell disease.

A 7-month-old female cat was seen for abnormal facial features and abnormality of gait. Facial dysmorphism, large paws in relation to body size, dysostosis multiplex, and poor growth were noted, and mucopolysaccharidosis was suspected. A negative urine test for sulfated glycosaminoglycans and extreme stiffness of skin indicated a mucolipidosis hitherto unknown in animals.

Rectal necrosis following anterior resection of the rectum.

Acute ischaemic colitis is a well recognized complication following abdominal surgery. It may occur spontaneously in older patients and is probably due to diffuse or localized obliterative arterial disease. In contrast, acute ischaemic proctitis is a rare clinical problem.

Influence of stevioside on hepatic glycogen levels in fasted rats.

The influence of stevioside, the sweet glycoside of Stevia rebaudiana leaves, on the glycogen levels of fasted rats was investigated. In one set of experiments, single doses of stevioside (200 mumol) or steviol (200 mumol) were given orally to 24-hours fasted rats, either alone or simultaneously with fructose. Under these conditions both stevioside and steviol increased the initial glycogen deposition in the liver.

Reproducibility of urethral pressure profiles in clinically normal sexually intact female dogs by use of microtransducer catheters.

Urethral pressures profiles (UPP) obtained by use of microtransducer catheters were determined in 8 anestrous sexually intact female Beagles during general anesthesia. A UPP study consisted of 3 consecutive recordings, and 4 UPP studies were repeated at an interval of 5 days in each dog. Maximal urethral pressure (cm of H2O), bladder pressure (cm of H2O), and anatomic urethral length (cm) were recorded.