Publications by authors named "Hubing Guo"
Background: Ossification of ligamentum flavum (OLF) is a prevalent degenerative spinal disease, typically causing severe neurological dysfunction. Kruppel-like factor 5 (KLF5) plays an essential role in the regulation of skeletal development. However, the mechanism KLF5 plays in OLF remains unclear, necessitating further investigative studies.
View Article and Find Full Text PDFArticle Synopsis
- A systematic review and meta-analysis investigated the link between preoperative prognostic nutritional index (PNI) and postoperative complications in adult spine surgery patients.
- The study included data from 10 cohort studies with a total of 3,249 patients, revealing that low PNI was significantly associated with a higher risk of complications, including delirium and surgical site infections.
- Findings suggest that assessing PNI before surgery could help identify patients at greater risk for complications, highlighting the importance of nutritional status in surgical outcomes.
Melanoma is a malignant tumor with high metastasis and mortality. Epithelial-mesenchymal transition (EMT) was reported to be involved in the growth and metastasis of melanoma. To investigate these sections further, we showed that E26 transformation specific 1 (ETS1) could regulate growth, metastasis and EMT process of melanoma by regulating microRNA(miR)-16/SRY-related HMG box (SOX) 4 expression.
View Article and Find Full Text PDFPurpose: To evaluate the clinical study efficacy and feasibility of 11 children with tuberculosis of the upper cervical spine treated by one-stage posterior debridement, short-segment fusion, and posterior instrumentation.
Methods: Eleven children who suffered from tuberculosis of the upper cervical spine were admitted to our hospital between June 2005 and December 2010. All of them were treated by one-stage posterior debridement, short-segment fusion, and posterior instrumentation.
Purpose: We evaluated the clinical efficacy and feasibility of one-stage posterior internal fixation, debridement and interbody thoracic fusion in the treatment of thoracic tuberculosis.
Methods: Sixty adult patients with monosegmental thoracic tuberculosis were studied retrospectively: 34 men and 26 women with an average age of 37.5 years.