Publications by authors named "Hubertus J M Frissen"
Article Synopsis
- Atherosclerotic plaques' destabilization is linked to the presence of specific microvessels, which might be leaky, although evidence is still needed.
- This study aimed to find key molecular drivers of dysfunction in these vessels by analyzing transcriptome data from human atherosclerotic lesions and identifying crucial genes related to microvascular density and inflammation.
- The research highlighted Spectrin Beta Non-Erythrocytic 1 (sptbn1) as a central gene that, when silenced, increased vascular permeability and inflammation, suggesting it plays a significant role in regulating the leaky characteristics of plaque microvessels related to cardiovascular disease.
