Publications by authors named "Hubert Loewenheim"

Objective: Peduncular hallucinosis is a rare phenomenon characterized by visual hallucinosis and agitation. It appears mainly in vascular lesions affecting the brainstem, and some recent reports describe the preoperative and postoperative appearance of peduncular hallucinosis in patients affected through tumor compression at the brainstem.

Methods: Detailing the neurosurgical experiences with this syndrome, we review the available literature and provide pathoneurobiological insights to give the neurosurgeon an overall view of this phenomenon.

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Constitutive activation of the ras oncoprotein plays a critical role in cancer invasion and metastasis. Particularly, ras-related protease expression such as the serine protease urokinase plasminogen activator (u-PA) has been implicated in mediating cancer cell invasion. Previous studies have shown that ras-mediated u-PA expression is regulated through the mitogen- (MAPK) and stress-activated protein kinase (SAPK) signal transduction pathways extracellular signal-regulated kinase (ERK) and c-Jun-activating kinase (JNK).

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