Publications by authors named "Hubert Kuebler"
Purpose: To date, over 4.2 million Germans and over 235 million people worldwide have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Uro-oncology (UO) patients are particularly vulnerable but in urgent need of life-saving systemic treatments.
View Article and Find Full Text PDFObjective: Novel strategies for the treatment of advanced prostate cancer (CaP), including immunotherapy or gene therapy, are currently under evaluation with Sipuleucel-T as first FDA-approved immunotherapeutic. Here, we examine cytosine-phosphorothioate-guanine (CpG)-DNA oligonucleotides (ODN) to boost cytokine responses and costimulatory molecule expression on murine bone marrow-derived dendritic cells (mBMDC). Furthermore, we evaluate the potency of a PSA-peptide based vaccine in combination with CpG-DNA to elicit specific cytotoxic T cell (CTL) responses.
View Article and Find Full Text PDFArticle Synopsis
- The study looked at how well a special scan called [(11)C]choline PET/CT can find and locate prostate cancer based on the shape of the tumor in tissue samples.
- 43 patients were involved, and their tumors were classified into different shapes, with results showing that the scan detected cancer in 79% of them, mostly on the same side.
- The research concluded that the shape of the tumor can make it harder to find prostate cancer using this scan, and it didn't do a great job telling cancer apart from other prostate conditions.
Article Synopsis
- Researchers looked at how patient backgrounds and experiences affected their choices in different prostate cancer surgeries, especially a new robot-assisted method.
- They found that the type of surgery didn’t seem to be influenced by patients’ age, race, or other factors, but there were some differences in health scores based on income and education.
- Overall, there was no clear sign that patients were choosing the robot-assisted surgery just because it was new, but the research showed some interesting trends in health quality based on patient backgrounds.
Objectives: To prospectively assess the health-related quality-of-life outcomes of patients undergoing robot-assisted laparoscopic prostatectomy using a validated patient self-assessment questionnaire.
Methods: Patients undergoing robot-assisted laparoscopic prostatectomy between September 2003 and May 2005 were given the Expanded Prostate Cancer Index Composite questionnaire preoperatively and 1, 3, 6, 9, 12, and 18 months postoperatively. Patients with a minimum follow-up of 3 months were included in the analysis.