Publications by authors named "Hubert Fan"
Article Synopsis
- Glucagon-like peptide-1 receptor agonists, like exenatide, offer benefits for type 2 diabetes patients including better blood sugar control, weight loss, and lower cardiovascular risks, leading to a study aimed at finding genetic factors influencing drug effectiveness.
- A pilot study involving 62 healthy volunteers tested exenatide versus saline, revealing that exenatide significantly boosted insulin secretion and glucose clearance but had a minimal effect on insulin sensitivity.
- The findings highlight the importance of specific glucose metabolism measurements and support further research to explore genetic influences on the effectiveness of diabetes medications like semaglutide.
Article Synopsis
- GLP1R agonists, like exenatide, help manage type 2 diabetes by improving blood sugar control, promoting weight loss, and reducing cardiovascular risks, but individual responses to these drugs differ widely.
- Exenatide significantly enhanced insulin secretion and glucose disappearance in a study involving 62 healthy volunteers, indicating its potential impact on glucose metabolism.
- The findings validate the use of the FSIGT method for ongoing research into how genetic factors may influence responses to GLP1R agonists, highlighting key measures like insulin secretion and glucose effectiveness.
Objective: To examine the ethnic differences in insulin sensitivity (S) as measured by the minimal model approach (S-MM) and the reference method, the euglycemic-hyperinsulinemic clamp (EHC).
Research Design And Methods: In a prospective study design, thirty Black Americans (BA) were age, sex, and BMI matched with non-Hispanic Whites (NHW). Participants underwent frequently sampled intravenous tolerance test (FSIVGTT) and EHC on 2 separate days during a single visit.