Publications by authors named "Hubert Ducou-Le-Pointe"

Article Synopsis
  • ChILD is a group of rare and severe lung diseases in children, with some cases linked to deficiencies in surfactant protein B (SP-B).
  • The RespiRare network helps to gather detailed information about the characteristics and genetic backgrounds of these patients.
  • A study involving 11 patients found that those with complete SP-B deficiency showed symptoms at birth and had a median survival of 1 month, while rarer cases with partial SP-B function might have a better chance of survival.
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Posterior fossa anomalies are less common in prenatal diagnosis than midline anomalies or ventricular dilatations. However, they constitute an important entity, combining neurological disorders as well as normal variants that should be recognized in prenatal diagnosis because of the genetic implications and neurodevelopmental outcome of some of these conditions. Here we present some of the main imaging features enabling prenatal diagnosis of posterior fossa anomalies in a context of constantly evolving classifications, resulting from advances in genetics and neuroimaging.

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Introduction: Total nephrectomies for the treatment of Wilms' tumor (WT) are more and more performed by laparoscopy, although indications for this approach following the UMBRELLA guidelines are currently very restrictive. The purpose of this study was to assess the compliance to the criteria of the UMBRELLA protocol for minimally invasive approach of WT.

Methods: This retrospective multicenter study included children operated on by laparoscopic total nephrectomy for suspected WT before 2020.

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Background: Abdominal radiographs remain useful in newborns. Given the high radiation sensitivity of this population, it is necessary to optimize acquisition techniques to minimize radiation exposure.

Objective: Evaluate the effects of three additional filtrations on radiation dose and image quality in abdominal X-rays of newborns using an anthropomorphic phantom.

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Article Synopsis
  • A study examined the prevalence and incidence of interstitial lung disease in children (chILD) in France, finding it affects 44 children per million in 2022 and has an incidence of 4.4 per million.
  • The research included data from 790 patients across 42 centers, noting that the median age for diagnosis was 3 months, with a significant portion having familial forms.
  • Management typically involved oxygen therapy and corticosteroids, with survival rates being 57.3% for children diagnosed before 2 years and 86% for those diagnosed between 2 and 18 years; the study highlights the need for improved international data collection and standardized practices.
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  • Juvenile Xanthogranuloma (JXG) is a rare condition primarily affecting infants, often posing diagnostic challenges, especially when lesions are located outside the skin.
  • This study involved analyzing the imaging characteristics of 11 patients with JXG in the head and neck using various imaging modalities such as ultrasound, MRI, and CT.
  • Key findings suggest that JXG lesions are typically well-defined with specific imaging features, including mild hyper-intensity on T1-weighted MRI, hypo-intensity on T2-weighted MRI, and potential bone involvement, which can help in diagnosing the condition.
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Article Synopsis
  • - The study evaluated the effectiveness of CT venography (CTV) in diagnosing venous thromboembolism (VTE) in women during the postpartum period across 14 hospitals from 2016 to 2020.
  • - A total of 123 women were analyzed, revealing that CTV helped identify additional cases of VTE that CT pulmonary angiography (CTPA) missed, increasing the detection rate from 5.7% to 12.2%.
  • - While CTV improved VTE detection, it also resulted in higher radiation exposure compared to CTPA alone, which raises considerations for clinical practice when managing postpartum PE.
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  • The study investigates the increasing exposure of healthcare workers to ionizing radiation (IR) and evaluates their compliance with radiation protection (RP) policies based on their perceived risk and occupational exposure.
  • It involves healthcare workers from a French hospital, analyzing dosimetric records and responses to an online questionnaire regarding their IR exposure, risk perception, and RP knowledge.
  • Results indicate that feeling exposed to IR significantly correlates with adherence to dosimeter use and RP practices, while non-compliance is often due to inadequate RP devices, highlighting the need for improved training and awareness among workers about their exposure risks.
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RISKS OF RADIODIAGNOSTIC EXAMINATIONS IN CHILDREN. The question of cancer risk associated with diagnostic medical exposure during childhood is important in view of the sharp increase in the use of radiological examinations, particularly computed tomography (CT), since the 2000s. Moreover, children represent a population particularly sensitive to ionizing radiation.

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Objectives: The neurotrophic tyrosine receptor kinase (NTRK) fusion transcript (FT) is a major genetic landmark of infantile fibrosarcoma (IFS) and cellular congenital mesoblastic nephroma (cCMN) but is also described in other tumours. The recent availability of NTRK-targeted drugs enhances the need for better identification. We aimed to describe the anatomic locations and imaging features of tumours with NTRK-FT in children.

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Introduction: Lung biopsy is considered as the last step investigation for diagnosing lung diseases; however, its indication must be carefully balanced with its invasiveness. The present study aims to evaluate the diagnostic yield of lung biopsy in critically ill patients hospitalized in the pediatric intensive care unit (ICU).

Material And Methods: Children who underwent a lung biopsy in the ICU between 1995 and 2022 were included.

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Background: Advances in surgical and neonatal care have led to improved survival of patients with œsophageal atresia (OA) over time. Morbidity remains significant, with one-third of patients being affected by a postoperative complication. Several aspects of management are not consensual, such as the use of œsophagogram before starting oral feeding.

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Nodular Lymphocyte predominant Hodgkin lymphoma (NLPHL) are rare lymphomas in pediatric patients comprising less than 10 % of all Hodgkin lymphoma (HL). They are for the most part diagnosed at stage I or II and indolent with lymphadenopathy often preceding the diagnosis by many months/years. Survival is excellent.

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Article Synopsis
  • Health workers make up over 50% of those exposed to man-made radiation in France, and the study (EXPoRTS) focuses on evaluating radiation exposure trends from 2009 to 2019.
  • The study analyzed dosimetric records from 1457 health workers, finding that overall radiation exposure significantly decreased over the decade; however, exposure varied greatly by profession, with radiologic technologists and physicians being the most exposed.
  • The findings indicate a need for targeted radiation safety measures, particularly for high-exposure groups like those in nuclear medicine.
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Article Synopsis
  • This study focuses on a rare prenatal diagnosis, specifically vermian cysts in fetuses, which had not been reported before.
  • Sixteen fetuses were included in the study, primarily female, with the cysts located in the vermian horizontal fissure, and all posterior fossa structures were found to be normal.
  • Postnatal outcomes for the majority were positive, with most children showing normal psychomotor development and no serious complications, although a few had minor developmental delays.
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Background: As the number of conventional radiographic examinations in pediatric emergency departments increases, so, too, does the number of reading errors by radiologists.

Objective: The aim of this study is to investigate the ability of artificial intelligence (AI) to improve the detection of fractures by radiologists in children and young adults.

Materials And Methods: A cohort of 300 anonymized radiographs performed for the detection of appendicular fractures in patients ages 2 to 21 years was collected retrospectively.

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Pre- and post-pubertal testicular tumors are two distinct entities in terms of epidemiology, diagnosis and treatment. Most pre-pubertal tumors are benign; the most frequent are teratomas, and the most common malignant tumors are yolk-sac tumors. Post-pubertal tumors are similar to those found in adults and are more likely to be malignant.

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Objectives: Increased risks of central nervous system (CNS) tumors and leukemia associated with computed tomography (CT) exposure during childhood have been reported in recent epidemiological studies. However, no evidence of increased risks was suggested in a previous analysis of the French CT cohort. This study benefits from an updated cohort with a longer follow-up and a larger sample size of patients.

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A wide spectrum of disorders involves the parotid glands, in infancy and childhood. Acute or chronic inflammatory/infectious diseases are predominant. The first branchial cleft anomalies are congenital lesions that typically manifest during childhood.

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Background: Hordeum murinum is a specie of grass rarely reported among the aspirated foreign body. It has high tissue penetration power and may cause lung damages.

Case Presentation: We report the case of a 15-month-old girl who choke while playing in the grass without any evident cause.

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Objectives: The aim of the study was to report a subtype of dysraphism designated as myelic limited dorsal malformation (MyeLDM) and to describe its characteristics at prenatal ultrasound (US).

Methods: It was a retrospective study from 2014 to 2020 based on second-line US evaluation of patients referred to our institution for myelomeningocele (MMC). Magnetic resonance imaging and acetylcholine esterase evaluation in the amniotic fluid were also offered.

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