Publications by authors named "Hubert De Belenet"
Am J Cancer Res
June 2021
Article Synopsis
- Liposarcomas are a diverse group of tumors categorized into subtypes, with treatment primarily involving complete surgical removal and possibly radiotherapy to prevent recurrence.
- Dedifferentiated liposarcomas (DDLS) show low sensitivity to chemotherapy and share significant genetic abnormalities, particularly amplifications on chromosome 12, which are being investigated for targeted therapies in clinical trials.
- Research focused on the genomic characteristics of DDLS revealed various alterations affecting tumor suppressor genes and highlighted the role of p53 in tumor development, linking it to Li-Fraumeni syndrome, a condition that increases sarcoma risk.
