Optimal Maternal Ventilation During Laparotomy with General Anesthesia in Pregnancy in the Ovine Model.

Background: General anesthesia during pregnancy is not uncommon, for example, for trauma surgery, cerclage, or cesarean delivery. Current recommendations are to maintain maternal partial pressure of carbon dioxide in arterial blood (paCO2) at 30 mm Hg, which is based solely on the average maternal paCO2 in awake pregnant women. However, there is no evidence that this target, compared to other targets, would enable optimal conditions for the fetus during general anesthesia.

Impact of intra-abdominal drains in emergency gastrointestinal surgery: a scoping review.

Introduction: Intra-abdominal drains are often placed in emergency gastrointestinal surgery procedures with the aim to prevent the formation of intra-abdominal collections (IAC) and aid in their early detection. However, the evidence for this is debated. This scoping review aims to evaluate the current evidence for their use in this setting.

Early antenatal risk factors for births before arrival: An unmatched case-control study.

Introduction: Birth before arrival is associated with maternal morbidity and neonatal morbidity and mortality. Yet, timely risk stratification remains challenging. Our objective was to identify risk factors for birth before arrival which may be determined at the first antenatal appointment.

Preclinical evidence for anaesthesia-induced neurotoxicity.

Preclinical research concerning anaesthesia-induced neurotoxicity was initiated in 1999. A decade later, the earliest clinical observational data showed mixed results in neurodevelopmental outcomes following anaesthesia exposure at a young age. Hence to date, preclinical studies remain the cornerstone of research in this field, primarily because of the vulnerability of clinical observational studies to confounding bias.

What should we tell parents? Congenital diaphragmatic hernia.

Congenital diaphragmatic hernia (CDH) is characterized by a defect in the muscle dividing the thoracic and abdominal cavities. This leads to herniation of the abdominal organs into the thorax and a disturbance of lung development. Two-thirds of cases are identified by prenatal ultrasound in the second trimester, which should prompt referral to a tertiary center for prognosis assessment and counseling by a multidisciplinary team familiar with this condition.

Digital images of pediatric mental disorders do not accurately represent the conditions.

Objective: Digital images might contribute to stigma associated with mental disorders. The aim of this study was to investigate whether these images accurately represent pediatric mental disorders, as well as to explore specific image-related factors that influence perception.

Methods: Four hundred pictures were retrieved from three stock photograph websites ('Shutterstock', 'iStock' and 'Adobe') and 'Google Images' for mental disorders (ADHD, ASD, and depression) and somatic diseases (asthma, diabetes, and influenza) in childhood.

Pelvic MRI in spinal cord injury patients: incidence of muscle signal change and early heterotopic ossification.

Study Design: Prospective observational study.

Objective: To evaluate pelvic MRI muscle signal changes and their association with early heterotopic ossification (HO) in patients with spinal cord injuries.

Setting: National Spinal Injuries Unit, Stoke Mandeville, UK.

Atypical responses of a large catchment river to the Holocene sea-level highstand: The Murray River, Australia.

Three-dimensional numerical modelling of the marine and fluvial dynamics of the lower Murray River demonstrate that the mid-Holocene sea-level highstand generated an extensive central basin environment extending at least 140 kilometres upstream from the river mouth and occupying the entire one to three kilometre width of the Murray Gorge. This unusually extensive, extremely low-gradient backwater environment generated by the two metre sea-level highstand captured most, if not all, of the fine-grained sediment discharged from the 1.06 million square kilometre Murray-Darling catchment.

Modelling Holocene analogues of coastal plain estuaries reveals the magnitude of sea-level threat.

Hydrodynamic modelling of Australia's lower Murray River demonstrates the response of a large coastal plain estuary to the mid-Holocene (7,000-6,000 yr BP) sea-level highstand. The approximately two metre higher-than-present sea level during the highstand forced the estuarine limit upstream generating an extensive central basin environment extending more than 200 kilometres from the river mouth (143 kilometres upstream of the modern tidal limit). The geomorphic history of the region does not conform to conventional estuarine facies models as, for much of the Holocene, the lower Murray River acted as a landward, gorge-confined extension of the Murray estuary.

Monte Carlo simulations of surface energy of the open tetrahedral surface of 2:1-type phyllosilicate.

Monte Carlo simulations were employed to investigate the surface energy of the open tetrahedral surface of 2:1-type phyllosilicate. Argon was selected as the probe molecule. The adsorption isotherm was simulated and the adsorption potential map was calculated.

Influence of Enterococcus faecalis proteases and the collagen-binding protein, Ace, on adhesion to dentin.

Enterococcus faecalis is a pathogen that persists in medicated root canals. Here, we tested the hypothesis that the E. faecalis proteases, serine protease and gelatinase, and the collagen-binding protein (Ace) contribute to adhesion to the root canal.