Publications by authors named "Huaying Liang"
Lung cancer (LC) remains one of the most common malignant tumours worldwide, and assessment of its progression is important for ensuring better prognostic outcomes for patients. This study was designed to explore the prognostic role of certain indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutritional index (PNI) in patients with LC, to help clinics to better determine the prognosis of patients with LC, and to allow them to intervene in a timely manner. A retrospective analysis of 116 initially diagnosed patients with LC in China from 2018 to 2020 was conducted.
View Article and Find Full Text PDFBackground And Objectives: Telomere length (TL) has been acknowledged as biomarker of biological aging. Numerous investigations have examined associations between individual early life factors and leukocyte TL; however, the findings were far from consistent.
Research Design And Methods: We evaluated the relationship between individual and combined early life factors and leukocytes TL in middle and late life using data from the UK Biobank.
Background: Sedentary behavior (SB) has emerged as a significant health concern that deserves attention. This study aimed to examine the associations between prolonged sedentary behavior and the risk of all-cause and cause-specific mortality as well as to explore desirable alternatives to sitting in terms of physical activity (PA).
Methods: Two prospective cohort investigations were conducted using the UK Biobank and NHANES datasets, with a total of 490,659 and 33,534 participants, respectively.
Background: Health problems associated with shift work and night shift work are gaining increasing public attention.
Objective: To investigate the association between night shift work and the hazard of mortality.
Design: Prospective cohort study.
Background: Although it is widely acknowledged that long-term exposure to ambient air pollution is closely related to the risk of mortality, there were inconsistencies in terms of cause-specific mortality and it is still unknown whether lifestyle and genetic susceptibility could modify the association.
Methods: This population-based prospective cohort study involved 461,112 participants from the UK Biobank. The land-use regression model was used to estimate the concentrations of particulate matter (PM, PM, PM), and nitrogen oxides (NO and NO).
Background: Several characteristics distinguish lung cancer in female patients from that in male patients, with adenocarcinoma being more prevalent in female patients and occurring more frequently in female patients who do not smoke. Uncertainty surrounds the relationship between female-specific reproductive factors and lung cancer risk.
Research Question: Are sex-specific reproductive factors associated with risk of lung cancer in different genetic risk groups and histologic types?
Study Design And Methods: A Cox proportional hazard model was used to evaluate the association between multiple reproductive factors and the risk of lung cancer developing in a prospective cohort study involving 273,190 female individuals from the UK Biobank.
Objectives: Leukocyte telomere length (LTL) is associated with a wide variety of diseases, including cancer. However, findings regarding the association between LTL and the risk for lung cancer have been inconclusive and inconsistent across previous observational studies.
Methods: This prospective cohort study included data from 425,146 participants 37-73 years of age housed in the UK Biobank.
Introduction: Vitamin D has been known to be associated with asthma, particularly in children, while the evidence among adults is limited and inconclusive. This study aimed to investigate the association between serum, vitamin D concentrations, and the incidence of adult-onset asthma and also the modified effect caused by sleep patterns and genetic risks.
Methods: A prospective cohort study with 307,872 participants aged between 37 and 73 years was conducted based on the UK Biobank, with a median follow-up of 12 years.
Background: Numerous studies have explored the association of air pollution with asthma but have yielded conflicting results. The exact role of air pollution in the incidence of adult-onset asthma and whether this effect is modified by genetic risk, lifestyle, or their interaction remain uncertain.
Methods: We conducted a prospective cohort study on 298,738 participants (aged 37-73 years) registered in the UK Biobank.
Background: Both genetic and lifestyle factors contribute to the development of asthma, but whether unfavourable lifestyle is associated with similar increases in risk of developing asthma among individuals with varying genetic risk levels remains unknown.
Methods: A healthy lifestyle score was constructed using body mass index, smoking status, physical activities and dietary pattern to further categorise into ideal, intermediate and poor groups. Genetic risk of asthma was also categorised as three groups based on the tertiles of polygenic risk score established using 212 reported and verified single-nucleotide polymorphisms of European ancestry in the UK Biobank study.
Background: Multiple studies showed sex discrepancies in the prevalence, incidence, and disease control of asthma. The relationships between different reproductive factors and the risk of asthma in females remain uncertain.
Design: A prospective cohort study recruited 239,701 female participants from the UK Biobank.
Clinical characteristics of severe coronavirus disease 2019 patients with chronic obstructive pulmonary disease.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
December 2022
Objectives: Coronavirus disease 2019 (COVID-19) in elderly and patients with chronic respiratory diseases (COPD) had a poor prognosis. COPD is one of the most common chronic respiratory diseases. We explore the epidemiological characteristics of patients with severe COVID-19 with COPD patients in order to provide medical evidence for the prevention and treatment of severe COVID-19.
View Article and Find Full Text PDFObjectives: The effect of air pollution exposure on incident lung cancer remains uncertain, and the modifying role of lifestyle and genetic susceptibility in association between air pollution and lung cancer is ambiguous.
Methods: A total of 367,623 participants from UK biobank cohort were enrolled in the analysis. The concentrations of particle matter (PM, PM), nitrogen dioxide (NO), and nitrogen oxides (NO), were evaluated by land-use regression model.
Clinical characteristics and prognosis of patient with leptospirosis: A multicenter retrospective analysis in south of China.
Front Cell Infect Microbiol
November 2022
Article Synopsis
- Leptospirosis, a disease caused by pathogenic spirochetes from the genus Leptospira, lacks a standardized definition and diagnostic criteria for its severe forms, highlighting the need for deeper understanding of its clinical aspects.
- A study analyzed 95 patients to identify distinct clinical types of leptospirosis using methods like multiple correspondence analysis, revealing three types: mild, respiratory, and hepato-renal leptospirosis, each with varying symptoms, hospital stays, and outcomes.
- Key findings indicated a 15.8% mortality rate linked to dyspnea and elevated neutrophil levels, suggesting these factors could help predict severe cases of the disease.
Background: Previous observational studies investigated the relationship between coffee and tea intake and the risk of asthma, however, the conclusions were inconsistent. Further, the combined effect of coffee and tea consumption on asthma has rarely been studied. Methods: We examined associations between the self-reported intake of tea and coffee and the risk of incident asthma in a total of 424,725 participants aged from 39 to 73 years old from the UK Biobank.
View Article and Find Full Text PDFBackground: Vitamin D has been known to be associated with asthma. However, the association between vitamin D status and asthma, lung function as well as hospitalization among adults remains unclear.
Objective: To investigate the role of serum vitamin D in asthma prevalence, lung function, and asthma control in adults.
Alveolar epithelial cell damage is an important determinant of the severity of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). However, the molecular mechanisms of alveolar epithelial death during the development of ALI/ARDS remain unclear. In this study, we explore the role of miR-29a-3p in ALI/ARDS and its molecular mechanism.
View Article and Find Full Text PDFObjective: (TM) is an opportunistic fungus that is predominantly prevalent among patients who are HIV-positive in South-East Asia. However, few studies focused on the clinical features, laboratory findings, and prognosis across varying immune states.
Methods: A total of 54 patients with TM infection in Xiangya Hospital of Central South University from January 1, 2006 to October 31, 2021 were retrospectively analyzed.
The south Gangdese region is the site of subduction of the Neo-Tethys and subsequent continental collision. Compared with widespread Cretaceous and Cenozoic magmatism, Early-Middle Jurassic magmatic rocks and related deposits are rarely reported. Our work identified a >200km long felsic rock belt associated with Cu mineralization in the south Gangdese region.
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