Publications by authors named "Huayi Sun"
Objective: This research aimed to delineate the pharmacological mechanisms of 7-Hydroxycoumarin (7-HC) on ulcerative colitis (UC) employing network pharmacology and experimental validation.
Methods: To investigate the therapeutic effects of 7-HC on UC, a UC mouse model was established through the unrestricted intake of 3.0% dextran sulfate sodium (DSS) in their drinking water.
Article Synopsis
- Sarcopenia is a muscle disorder in which there is a significant loss of muscle mass and function, with few effective drug treatments available.
- The study discovered a strong link between low selenium levels in the blood and muscle function in elderly individuals suffering from sarcopenia, leading researchers to suggest that selenium supplementation could help manage this condition.
- Researchers developed nanoparticles that release selenium and leucine, which improved muscle function by regulating certain cell signaling pathways and showed promise as a safe and effective treatment for sarcopenia.
Article Synopsis
- - Adipose tissue is a key player in obesity, serving as a major source of circulating microRNAs (miRNAs) which may help predict obesity-related health issues.
- - A systematic review collected data from various databases and identified thirty miRNAs linked to obesity, along with seventy-nine validated targets relating to multiple obesity-related diseases.
- - The study explored the mechanisms of miRNA production and their connections to various biological pathways, aiding in understanding the epigenetic factors involved in obesity-related health complications.
Article Synopsis
- Progerin, a mutated protein, causes severe nuclear abnormalities in patients with Hutchinson-Gilford progeria syndrome (HGPS), which is a condition that leads to premature aging.
- The research shows that problems with the IGF-1R/Akt signaling pathway in a mouse model contribute to growth issues and accelerated aging due to progerin's mislocalization and negative impact on mitochondrial function.
- Treatment with a specific drug boosts Akt activity and helps alleviate multiple symptoms in progeroid mice, suggesting potential therapeutic approaches for related aging disorders.
In multiple types of cancer, decreased tumour cell apoptosis during chemotherapy is indicative of decreased chemosensitivity. Forkhead box K2 (FOXK2), which is essential for cell fate, regulates cancer cell apoptosis through several post-translational modifications. However, FOXK2 acetylation has not been extensively studied.
View Article and Find Full Text PDFProlonged heart rate-corrected QT (QTc) interval is an independent risk factor for sudden cardiac death, which is the hallmark of Timothy syndrome (TS). There are little data on children with syndactyly and QTc prolongation.To evaluate the characteristics and long-term outcomes in children with syndactyly, and to attempt to identify TS in patients with syndactyly and QTc prolongation.
View Article and Find Full Text PDFBackground: There are inconsistent interpretations of the interrelationship of adiposity, anthropometric indices, and blood pressure (BP) in hypertensive patients. Additionally, whether these relationships differ between sexes is unknown. We aimed to elucidate the associations of adiposity indices measured using quantitative computed tomography (QCT) with BP and hypertension and to determine the effect of sex on the interrelationship of these parameters in a Chinese population.
View Article and Find Full Text PDFLong noncoding RNAs (lncRNAs) are found to be aberrantly expressed and pose significant impacts in colorectal cancer (CRC), the most prevalent type malignancy in the gastrointestinal tract. This study aimed to find out the regulation of lncRNA EIF3J antisense RNA 1 (EIF3J-AS1) on CRC progression. Expressions of EIF3J-AS1, microRNA-3163 (miR-3163), and Yes-associated protein 1 (YAP1) in tissues and cells were evaluated by real-time quantitative polymerase chain reaction (RT-qPCR) and Western blot analysis.
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