Publications by authors named "Huaye Chen"
Micronuclei in 2-cell embryos show higher blastocyst formation rates on human embryonic development.
Eur J Obstet Gynecol Reprod Biol
November 2024
Objective: Multinucleated blastomeres at the two-cell stage (2MNB) represent a frequently observed nuclear abnormality in early human embryos. This abnormality has been reported to significantly impact on the embryo's developmental potential to reach the blastocyst stage. However, our understanding of the embryo's developmental potential and the morphokinetics of 2MNB remains limited.
View Article and Find Full Text PDFFraser syndrome is a rare autosomal recessive malformation disorder. It is characterized by cryptophthalmos, syndactyly, urinary tract abnormalities and ambiguous genitalia. This condition is due to homozygous or heterozygous mutations in the , , , and genes In the present study, we recruited a Chinese family with Fraser syndrome.
View Article and Find Full Text PDFArticle Synopsis
- - This study examined prenatal diagnosis for α-thalassemia and β-thalassemia in over 3,000 families across Hainan Province, using molecular techniques to analyze DNA from parents and their fetuses.
- - The researchers identified specific gene mutations: the most frequent for α-thalassemia was SEA/αα (31.53%), while for β-thalassemia it was CD41/42 (30.27%), with prevalence varying by region.
- - Out of the examined fetuses, 556 were normal, 116 had α-thalassemia hydrops, and 134 had β-thalassemia major, highlighting the need for effective genetic counseling in this area.