Publications by authors named "Huaxiang Leng"
Article Synopsis
- Alzheimer's disease (AD) is a progressive neurodegenerative condition, prompting research into effective early diagnostic biomarkers, particularly focusing on amyloid-β aggregates and mitochondrial viscosity.
- The study introduces C25e, a GFP-based red-emissive fluorescent probe, which successfully detects β-amyloid plaques and measures mitochondrial viscosity using distinct fluorescence signals at approximately 624 nm and 640 nm.
- C25e has shown superior selectivity and signal clarity compared to existing methods, positioning it as a promising dual-functional tool for early AD detection by imaging both amyloid-β plaques and mitochondrial viscosity changes.
β-Amyloid deposition is one of the main pathological features of Alzheimer's disease (AD). The development of fluorescent probes targeting specific β-amyloid species has recently become an attractive strategy to achieve the early diagnosis of AD. In this work, a dual-channel fluorescent protein chromophore derivative was rationally designed and synthesized for the detection and discrimination of Aβ aggregates and oligomers.
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- Two new BODIPY-based fluorescent rotors were developed to react sensitively to viscosity changes in living cells, showing a fluorescence "turn-on" effect.
- The increase in fluorescence is due to the restricted rotation of the -CF group in thicker environments.
- One of the probes, which includes a positively charged group, demonstrates effective targeting of mitochondria and exhibits an Aggregation-Induced Emission (AIE) property.