Molecular Mechanisms of circKIF4A in Breast Cancer Progression.

Aim: Breast cancer (BC) is the most frequently diagnosed malignancy worldwide, necessitating continued research into its molecular mechanisms. Circular RNAs (circRNAs) are increasingly recognized for their role in various cancers, including BC. This study explores the role of circRNA kinesin family member 4A (circKIF4A) in BC progression and its underlying molecular mechanisms.

Biological electricity generation system based on mitochondria-nanochannel-red blood cells.

The high-efficiency energy conversion process in organisms is usually carried out by organelles, proteins and membrane systems. Inspired by the cellular aerobic respiration process, we present an artificial electricity generation device, aimed at sustainable and efficient energy conversion using biological components, to demonstrate the feasibility of bio-inspired energy generation for renewable energy solutions. This approach bridges biological mechanisms and technology, offering a pathway to sustainable, biocompatible energy sources.

Bio-inspired High-Performance Artificial Ion Pump Mediated by Subnanoscale Dehydration Hydration Effects.

The energy conversion in plant chloroplast is carried out by pumping protons into the thylakoid for driving ATP synthesis. Inspired by ion active transport in living organisms, we attempted to design an artificial ion pump induced by subnanoconfinement effects. This ionic device uses two polarity functional nanoporous films as ion-selective valves at both ends and UiO-66 metal-organic framework-filled microchannels as ion storage cavities.

Polyacrylonitrile nanofibrous membrane composited with zeolite imidazole skeleton-8 and silver nanoclusters for efficient antibacterial and emulsion separation.

Oily wastewater discharged by industrial development is an important factor causing water pollution. Membrane separation technology has the advantages of low cost, simple operation, and high efficiency in the treatment of oily wastewater. However, membrane materials are easily eroded by microorganisms during long-term storage or use, thereby resulting in reduced separation efficiency.

Bioinspired High-Strength Montmorillonite-Alginate Hybrid Film: The Effect of Different Divalent Metal Cation Crosslinking.

The natural nacre has a regular ordered layered structure of calcium carbonate tablets and ion crosslinking proteins stacked alternately, showing outstanding mechanical properties. Inspired by nacre, we fabricated different divalent metal cation-crosslinked montmorillonite-alginate hybrid films (MMT-ALG-X2+; X2+ = Cu2+, Cd2+, Ba2+, Ca2+, Ni2+, Co2+ or Mn2+). The effect of ionic crosslinking strength and hydrogen bond interaction on the mechanical properties of the nacre-mimetics was studied.

A procedure for comparing the ecological status and transformation measures in an anthropized coastal area.

The overall vitality and quality of the coastline can be improved through ecological transformation; ecological status assessment can scientifically guide this modification by putting forward a transformation plan for the coastline. This study took the Shenzhen Bay area between Hong Kong and Shenzhen as the study area to build an index system and combined it with quantitative and qualitative methods by designing the code of data processing, calculation, and analysis through the MATLAB platform, with the goal being to put forward the directions and suggestions for coastline transformation based on the analysis of results. The results and conclusions are as follows: (1) The key aspects of the ecological transformation of the Shenzhen Bay Coastline are water quality, coastal wetland restoration, landscape diversity, beach stability, and infrastructure improvement.

"Ion Pool" Structural Ion Storage Device: A New Strategy to Collect Ions by Nanoconfinement Effects.

Ion storage structure widely exists in organisms, which is used to harvesting energy in environment and converting it into ion concentration gradient to maintain complex life activities. The construction of ion storage structures relies on isolating the biological body fluids by biofilm systems, which can also be regarded as local ions confinement. Mimicking this ions storage process, an "ion pool" structural ion storage device is proposed in this research by artificial ion nanochannels, which can transform the electric power into ion concentration gradient.

Gap Confinement Effect of a Tandem Nanochannel System and Its Application in Salinity Gradient Power Generation.

As an important nanofluidic device, an artificial ion nanochannel could selectively transport ions inside its nanoconfinement space and the surface charge of the pore wall. Here, confinement effects were realized by tandem nanochannel units, which kept their cascade gaps less than 500 nm. Within these gaps, ionic conductance was governed by the surface charge density of the channel unit.

One-Step Fabrication of a Micro/Nanosphere-Coordinated Dual Stimulus-Responsive Nanofibrous Membrane for Intelligent Antifouling and Ultrahigh Permeability of Viscous Water-in-Oil Emulsions.

Membrane fouling is a major challenge for long-term oil/water separation. The incomplete degradation of organic pollutants or membrane damage exists in the common methods of membrane regeneration. Herein, a dual-responsive nanofibrous membrane with high water-in-oil emulsion separation efficiency and smart cleaning properties is reported, which shows complete restoration of its original separation performance.

Spatial Trade-Offs and Temporal Evolution of Multiple Ecosystem Services in a Marine-Terrestrial Urban-Agglomeration Zone.

It takes some time for changes to come in ecosystem services, and trade-offs occur in the process of changes. As opposed to a point in time, we use data spanning the years 2000-2005, 2005-2010, and 2010-2015 to study this research. After quantifying types of ecosystem services, this paper uses spatial correlation analysis and root-mean square deviation (RMSD) method to explore the relationships among ecosystem services and calculate the degree of spatial trade-offs (DT).

Insights into plasmon induced keto-enol isomerization.

Chemical reactions that are driven by plasmon-induced hot carriers are a timely topic of interest to chemists and material scientists as they provide catalytic alternatives that may reduce cost and/or waste. Herein, we monitored the localized surface plasmon resonance-induced keto-enol isomerization process of 2-mercapto-4(3H)-quinazolinone (MQ) by time-dependent surface enhanced Raman scattering (SERS), where the MQ molecules are adsorbed on gold nanoparticles (GNP) surface by Au-S bonds. The mechanism of keto-enol isomerization has been successfully investigated, and it is found that the isomerization is induced by hot hole transfer from GNPs to the adsorbed molecules.

Bioinspired Ternary Artificial Nacre Graphene Oxide/Carboxyl Functionalized Single-Walled Carbon Nanotubes/Konjac Glucomannan with Enhanced Mechanical Properties.

Inspired by the nacre layered multistage structure and high toughness and strength of the unity of mechanical properties, a graphene oxide/carboxyl functionalized single-walled carbon nanotubes/konjac glucomannan (GO-SC-KGM) nanocomposite is successfully fabricated through a vacuum filtration method for the first time. The GO nanosheets with carboxyl and hydroxyl groups, SC with carboxyl groups, and the KGM molecule chains with abundant hydroxyl groups could easily form hydrogen bonding networks, resulting in a strong interface interaction. The tensile strength of prepared GO-SC-KGM nanocomposites reaches 311.

Ion Transport Behaviors of Nanofluidic Diode Bichannel Systems in the Independent and Synergistic Cascade Mode.

The nanofluidic diode device was a significant ionic transistor. Its multiple cascades could realize diversified ion transport behaviors and information processing functions. Different cascade modes of channel units will affect the response current properties of multichannel systems.

A CO-tunable plasmonic nanosensor based on the interfacial assembly of gold nanoparticles on diblock copolymers grafted from gold surfaces.

A general stepwise strategy for the fabrication of CO-tunable plasmonic nanosensors was described for the first time, based on gold surface functionalization by CO-responsive poly(,-diethylaminoethyl methacrylate) (PDEAEMA) brushes a surface-initiated atom transfer radical polymerization (SI-ATRP) method, then the extremity of PDEAEMA was functionalized by linking the polyacrylamide (PAAm) brushes ATRP, where they were assembled with gold nanoparticles (AuNPs) efficiently by altering the deposition time. The swelling-shrinking states of the PDEAEMA brushes can be tuned just by passing CO and N through a solution alternately. The unique plasmonic surface-enhanced Raman scattering (SERS) sensing properties of these stimulable substrates were investigated using 4-mercaptophenol (4MPh) as a molecular probe.

Assessment of Regional Ecosystem Health-A Case Study of the Golden Triangle of Southern Fujian Province, China.

Intensifying urbanization and rapid population growth in Fujian Province, China, has caused pollution of air and water resources; this has adversely impacted ecosystems and human health. China has recently begun pursuing a massive infrastructure and economic development strategy called the Belt and Road Initiative, which could potentially cause further environmental damage. Evaluations of ecosystem health are therefore a first step towards identifying the potential impacts from the development and planning sustainable development strategies in the Golden Triangle of Southern Fujian.

Direct determination of the tumor marker AFP via silver nanoparticle enhanced SERS and AFP-modified gold nanoparticles as capturing substrate.

The authors describe a rapid and direct SERS-based immunoassay for the determination of AFP, an important marker for diagnosis of hepatocellular carcinoma. Silver nanoparticles (AgNPs; 36 nm i.d.