Viral expression of NE/PPE enhances anti-colorectal cancer efficacy of oncolytic adenovirus by promoting TAM M1 polarization to reverse insufficient effector memory/effector CD8 T cell infiltration.

Background: Oncolytic adenoviruses are among the most widely utilized oncolytic viruses due to their notable anti-tumor and gene expression capabilities, and modification of ADVs to create armed adenoviruses remains a popular research direction. Nonetheless, immune suppression triggered by ADV and targeted enhancements based on this limitation have been relatively unexplored.

Methods: Flow cytometry was employed to assess immune infiltration in the tumor microenvironment following ADV therapy.

First Report of Causing Leaf Spot on in China.

Dandelion (), belonging to the Asteraceae family, is one of the main associated species in the alpine meadow, and is famous for its both feeding and medicinal values (Lin et al. 2022; Wang et al. 2022).

Identification, Pathogenicity, and Fungicide Sensitivity of Species Associated with Anthracnose on Italian Ryegrass in Southwestern China.

Italian ryegrass ( L.) is widely cultivated as an important forage grass worldwide because of its high nutritional value and good palatability. Anthracnose caused by species was a common and new emerging disease of Italian ryegrass.

High Diversity of Species Associated with Leaf Spot on Italian Ryegrass in Southwestern China: Six New Records and Three New Species.

Italian ryegrass is widely cultivated for the production of forage, hay, and silage because of its high nutritional value and good palatability. Leaf spots caused by fungi pose a serious threat to forage crops. In order to expand the knowledge of fungi causing leaf spots in ryegrass () in Sichuan, Yunnan, Chongqing, and Guizhou of southwestern China, a comprehensive survey was undertaken from 2015 to 2022.

The impact of the gut microbiome on tumor immunotherapy: from mechanism to application strategies.

Immunotherapy is one of the fastest developing areas in the field of oncology. Many immunological treatment strategies for refractory tumors have been approved and marketed. Nevertheless, much clinical and preclinical experimental evidence has shown that the efficacy of immunotherapy in tumor treatment varies markedly among individuals.

First Report of Causing Leaf Spot on Italian Ryegrass in China.

Italian ryegrass () is widely cultivated for the production of forage, hay and silage worldwide, due to its high nutritional value and palatability (Feng et al. 2021). It has been infected by a number of foliar fungal diseases caused by different fungal pathogens (Xue et al.

Metabolomics-based discovery of XHP as a CYP3A4 inhibitor against pancreatic cancer.

Xihuang Wan (XHW), a purgative and detoxifying agent, is commonly utilized in modern medicine as a treatment and adjuvant therapy for various malignancies, including breast cancer, liver cancer, and lung cancer. A clinical study demonstrated the potential usefulness of the combination of XHW and gemcitabine as a therapy for pancreatic cancer (PC), indicating that XHW's broad-spectrum antitumor herbal combination could be beneficial in the treatment of PC. However, the precise therapeutic efficacy of XHW in treating pancreatic cancer remains uncertain.

Prediction of Sweet Corn Seed Germination Based on Hyperspectral Image Technology and Multivariate Data Regression.

Vigor identification in sweet corn seeds is important for seed germination, crop yield, and quality. In this study, hyperspectral image (HSI) technology integrated with germination tests was applied for feature association analysis and germination performance prediction of sweet corn seeds. In this study, 89 sweet corn seeds (73 for training and the other 16 for testing) were studied and hyperspectral imaging at the spectral range of 400-1000 nm was applied as a nondestructive and accurate technique to identify seed vigor.

An enhanced drought-tolerant method using SA-loaded PAMPS polymer materials applied on tobacco pelleted seeds.

Drought is one of the most important stress factors limiting the seed industry and crop production. Present study was undertaken to create novel drought-resistant pelleted seeds using the combined materials with superabsorbent polymer, poly(2-acrylamide-2-methyl propane sulfonic acid) (PAMPS) hydrogel, and drought resistance agent, salicylic acid (SA). The optimized PAMPS hydrogel was obtained as the molar ratio of 2-acrylamido-2-methyl-propanesulfonic acid (AMPS) to potassium peroxydisulfate (KPS) and N, N'-methylene-bis-acrylamide (MBA) was 1 : 0.