Study on pore structure and adsorption properties of coal and microscopic action mechanism of outburst.

Coal and gas outburst is a complex dynamic phenomenon happened in the underground of coal mines, and it has been a serious threat to the safe and efficient production of mines. To investigate the intricate mechanisms at play, a large-scale coal and gas outburst test was conducted based on the prototype of outbursts induced by coal uncovering. Coal samples were obtained through isometric excavation, grinding, and sieving, followed by an analysis of their pore structure and gas adsorption properties.

Investigating the Diagnostic and Therapeutic Potential of a T Cell Receptor (TCR)-like single Domain Antibody (sDAb)-Human IgG1 Antibody against Heat Shock Protein (HSP) 16KDa/HLA-A2 for Latent Tuberculosis.

Heat shock protein 16-kDa (HSP 16-kDa) is essential for the survival of () during the latent period; hence, a peptide-MHC presentation of HSP 16-kDa could be a potential diagnostic and therapeutic target for latent tuberculosis (LTB). This study aimed to generate a TCR-like single-domain antibody (sDAb)-human IgG1 antibody and subsequently investigate its diagnostic and therapeutic potential in LTB, utilizing a model cell presenting the target peptide. A previously generated TCR-like sDAB that can bind to HSP 16-kDa was first fused to a human IgG1 Fc-receptor via a linker.

The Future of TCR-like Antibodies in Diagnosis and Potential Application Targets.

The human leukocyte antigen (HLA, also known as the major histocompatibility complex or MHC) system, is responsible for immune monitoring of the intracellular proteome of all nucleated cells. The presentation of antigen peptides separates malignant or infected cells from their healthy counterparts and forms aberrant cells tagged as the foundation for identification. Therefore, peptide-MHC molecules can give potential diagnostic targets for cancer or infection.

The Impact of Academic Pressure and Peer Support on Adolescents' Loneliness: A Polynomial Regression and Response Surface Analysis.

Purpose: To explore the impact of the match between academic pressure and peer support on adolescents' sense of loneliness and examine whether social connectedness played a mediating role, using a polynomial regression and response surface analysis.

Methods: A questionnaire survey was conducted with 1277 adolescents from two cities in Sichuan Province, China, to investigate their academic pressure, peer support, social connectedness, and sense of loneliness.

Results: (1) Adolescents' sense of loneliness positively correlated with their level of academic pressure and negatively correlated with their degree of peer support.

Interfacial Characteristics and Mechanical Properties of CuSn15/HT250 Prepared via Additive Manufacturing Combined with an Inconel 718 Interlayer.

Tremendous discrepancies in the positive enthalpy of mixing and the coefficient of thermal expansion emerge between the copper alloy and the gray cast iron, accounting for numerous pores and cracks in the interfacial region during the metallurgical bonding process. To enhance the interfacial bonding properties of these two refractory materials, laser-directed energy deposition was applied to fabricate the CuSn15 alloy on the HT250 substrate; meanwhile, Inconel 718 alloy, acting as the interlayer, was added to their bonding region. Firstly, the effect of the deposition process on deposition layer quality was investigated, and then the effects of Inconel 718 addition on the interfacial morphology, element distribution, phase composition, bonding strength, microhardness were studied.

High Expression of ABRACL Is Associated with Tumorigenesis and Affects Clinical Outcome in Gastric Cancer.

Background: The ABRA C-terminal like (ABRACL) protein belongs to a novel family of low-molecular weight proteins that increase actin dynamics and cell motility. It is involved in various diseases including cancer; however, its role in gastric cancer is unclear. In this study, the expression of ABRACL in gastric cancer and its relationships with patients' clinicopathological features and survival are examined.

MicroRNA‑339‑5p inhibits cell proliferation of acute myeloid leukaemia by directly targeting SOX4.

In recent decades, microRNAs (miRNAs) have been considered novel gene regulators. Dysregulated miRNAs serve crucial roles in the formation and progression of acute myeloid leukaemia (AML). Therefore, the roles of differentially expressed miRNAs in AML require extensive investigation to obtain insight into the treatment of patients with AML.

miR-126 Suppresses Invasion and Migration of Malignant Glioma by Targeting Mature T Cell Proliferation 1 (MTCP1).

BACKGROUND The aim of this study was to assess the utility of miR-126 in promoting malignant glioma progression and determine if miR-126 might be a target for malignant glioma treatment. MATERIAL AND METHODS The expression of miR-126 in malignant glioma tissues and cells was detected by reverse transcription polymerase chain reaction (RT-PCR). Western blot analysis was used to detect changes in protein levels.

miR-15b Inhibits the Progression of Glioblastoma Cells Through Targeting Insulin-like Growth Factor Receptor 1.

The microRNAs (miRNAs) have been suggested as a tumor suppressor in recent years. miR-15b was reported to exert an anti-oncogenic role in the proliferation, migration, and invasion of diverse tumor cells. However, the mechanisms underlying miR-15b-mediated biology of glioblastoma are still unclear.

Hugl-1 inhibits glioma cell growth in intracranial model.

Drosophila lethal (2) giant larvae (lgl) has been reported as a tumor suppressor and could regulate the Drosophila hippo signaling. Human giant larvae-1(Hugl-1), one human homologue of Drosophila lgl, also has been reported to be involved in the development of some human cancers. However, whether Hugl-1 is associated with the pathogenesis of malignant gliomas remains poorly understood.

MicroRNA-490-3p regulates cell proliferation and apoptosis by targeting HMGA2 in osteosarcoma.

MicroRNA-490-3p (miR-490-3p) has been implicated in several human malignancies; however, its potential functions and the underlying molecular mechanisms in osteosarcoma progression remain largely unclear. Here, we showed that miR-490-3p was down-regulated in osteosarcoma cell lines. Ectopic expression of miR-490-3p decreased cell proliferation, induced G1 arrest and apoptosis in vitro and inhibited tumorigenicity in a mouse xenograft model.