Ultrathin high-entropy hydrotalcites-based injectable hydrogel with programmed bactericidal and anti-inflammatory effects to accelerate drug-resistant bacterial infected wound healing.

Drug-resistant bacteria infected wounds often bring high risks of delayed healing process and even death. Sonodynamic therapy (SDT) can efficiently kill drug-resistant bacteria. However, superabundant reactive oxygen species (ROS) generated during SDT inevitably trigger significant inflammatory responses, hindering tissue remodeling.

Rapidly in situ forming antibiotic-free injectable hydrogel wound dressing for eradicating drug-resistant bacterial infections in human skin organoids.

The rising prevalence of global antibiotic resistance evokes the urgent requirement to explore the alternative antimicrobial candidates. It is of great significance to overcome these serious threats of multidrug-resistant bacterial infections and difficult-to-heal cutaneous wounds to human health. Herein, we proposed a rapidly in situ forming innovative antibiotic-free hydrogel dressing with excellent biocompatibility, easy injectability, strong tissue adhesion and superior antibacterial activity against drug-resistant bacteria.

Bio-Inspired Microreactors Continuously Synthesize Glucose Precursor from CO with an Energy Conversion Efficiency 3.3 Times of Rice.

Excessive CO and food shortage are two grand challenges of human society. Directly converting CO into food materials can simultaneously alleviate both, like what green crops do in nature. Nevertheless, natural photosynthesis has a limited energy efficiency due to low activity and specificity of key enzyme D-ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO).

Rapid Segmentation and Diagnosis of Breast Tumor Ultrasound Images at the Sonographer Level Using Deep Learning.

Background: Breast cancer is one of the most common malignant tumors in women. A noninvasive ultrasound examination can identify mammary-gland-related diseases and is well tolerated by dense breast, making it a preferred method for breast cancer screening and of significant clinical value. However, the diagnosis of breast nodules or masses via ultrasound is performed by a doctor in real time, which is time-consuming and subjective.

Long noncoding RNA alleviates angiotensin II-induced cardiac hypertrophy phenotypes by mediating the miR-765/Wnt family member 7B pathway.

Long noncoding RNAs (lncRNAs) are known to participate in the pathological process of cardiac hypertrophy. This study aimed to investigate the function of the lncRNA, myosin heavy-chain associated RNA transcript (), in cardiac hypertrophy and its possible mechanism of action. Adult mouse cardiomyocytes were treated with angiotensin II (Ang II) and transfected with ; cardiac hypertrophy was evaluated by estimating atrial natriuretic peptide, brain natriuretic peptide, and beta-myosin heavy-chain levels, and cell surface area by reverse transcription-quantitative polymerase chain reaction, western blotting, and immunofluorescence staining.

Co-simulation of hypertensive left ventricle based on computational fluid dynamics and a closed-loop network model.

Objective: Hypertension is one of the most common chronic and cardiovascular diseases, with the largest number of deaths. According to clinical experience, long-term hypertension will cause cardiac hypertrophy and other complications, and heart structure remodeling will significantly change the energy characteristics of the heart chambers, and impair heart function. Research shows that, early hypertension can be diagnosed by the blood flow and energy loss in the left ventricle.

Molecular Dipole-Induced Photoredox Catalysis for Hydrogen Evolution over Self-Assembled Naphthalimide Nanoribbons.

D-π-A type 4-((9-phenylcarbazol-3-yl)ethynyl)-N-dodecyl-1,8-naphthalimide (CZNI) with a large dipole moment of 8.49 D and A-π-A type bis[(4,4'-1,8-naphthalimide)-N-dodecyl]ethyne (NINI) with a negligible dipole moment of 0.28 D, were smartly designed and synthesized to demonstrate the evidence of a molecular dipole as the dominant mechanism for controlling charge separation of organic semiconductors.

Sinomenine ameliorates cardiac hypertrophy by activating Nrf2/ARE signaling pathway.

Cardiac hypertrophy (CH) is a result of the physiological adaptation of the heart to coronary heart disease, hypertension, and other cardiovascular diseases. Sinomenine is extracted from . This study aimed to explore the specific mechanism of the action of sinomenine in cardiac hypertrophy (CH) via Nrf2/ARE signaling pathway and .

COVID-19 Diagnosis from CT Images with Convolutional Neural Network Optimized by Marine Predator Optimization Algorithm.

In recent years, almost every country in the world has struggled against the spread of Coronavirus Disease 2019. If governments and public health systems do not take action against the spread of the disease, it will have a severe impact on human life. A noteworthy technique to stop this pandemic is diagnosing COVID-19 infected patients and isolating them instantly.

Vector Flow Mapping Application in Local Cardiac Function in Hypertension Assessment.

Objective: This study aims to investigate the clinical significance of vector flow mapping (VFM) by observing and quantifying energy loss (EL) during different phases and in different left ventricle (LV) segments.

Methods: 42 healthy physical examination subjects and 89 patients with hypertension (HTN) were enrolled in the present study. The patients with HTN were divided into two groups: the left ventricular hypertrophy group (LVH) (n = 51) and the non-left ventricular hypertrophy group (NLVH) (n = 38), while the healthy patients were control group.

Skin Cancer Detection Using Kernel Fuzzy C-Means and Improved Neural Network Optimization Algorithm.

Early diagnosis of malignant skin cancer from images is a significant part of the cancer treatment process. One of the principal purposes of this research is to propose a pipeline methodology for an optimum computer-aided diagnosis of skin cancers. The method contains four main stages.

A systematic review for the efficacy of coenzyme Q10 in patients with chronic kidney disease.

Background: The effects of coenzyme Q10 (CoQ10) supplementation in chronic kidney disease (CKD) patients remain controversial.

Objective: A systematic review of current evidence was performed to systematically and comprehensively summarize the effects of CoQ10 on cardiovascular outcomes, oxidative stress, inflammation, lipid profiles, and glucose metabolism.

Methods: MEDLINE, EMBASE, and the Cochrane Library database (Cochrane Central Register of Controlled Trials) were searched to identify eligible studies investigating the effects of CoQ10 supplementation on patients with CKD.

Enhancing plasmonic hot-carrier generation by strong coupling of multiple resonant modes.

Plasmon-induced hot carriers have recently attracted considerable interest, but the energy efficiency in visible light is often low due to the short lifetime of hot carriers and the limited optical absorption of plasmonic architectures. To increase the generation of hot carriers, we propose to exert multiple plasmonic resonant modes and their strong coupling using a metal-dielectric-metal (MDM) nanocavity that comprises an Au nanohole array (AuNHA), a TiO thin film and an Au reflector. Unlike common MDM structures, in addition to the Fabry-Pérot mode in the dielectric layer, AuNHA as the top layer is special because it excites the localized surface plasmon resonance (LSPR) mode in the Au nanoholes and launches the gap surface plasmon polariton (GSPP) mode in the Au reflector surface.

Current Trends of Targeted Drug Delivery for Oral Cancer Therapy.

Oral cancer is an aggressive tumor that invades the local tissue and can cause metastasis and high mortality. Conventional treatment strategies, e.g.

Knowledge Graph Completion for the Chinese Text of Cultural Relics Based on Bidirectional Encoder Representations from Transformers with Entity-Type Information.

Knowledge graph completion can make knowledge graphs more complete, which is a meaningful research topic. However, the existing methods do not make full use of entity semantic information. Another challenge is that a deep model requires large-scale manually labelled data, which greatly increases manual labour.

Electric-Field-Mediated Electron Tunneling of Supramolecular Naphthalimide Nanostructures for Biomimetic H Production.

The design and synthesis of two semiconducting bis (4-ethynyl-bridging 1, 8-naphthalimide) bolaamphiphiles (BENI-COO and BENI-NH ) to fabricate supramolecular metal-insulator-semiconductor (MIS) nanostructures for biomimetic hydrogen evolution under visible light irradiation is presented. A H evolution rate of ca. 3.

Effects of coenzyme Q10 on endothelial and cardiac function in patients undergoing haemodialysis: study protocol for a pilot randomised controlled trial.

Introduction: Endothelial and cardiac dysfunction are highly prevalent and are associated with cardiovascular morbidity and mortality among patients undergoing dialysis. For patients undergoing dialysis, no study has explored the effect of supplementation of coenzyme Q10 (CoQ10) on endothelial function. To our best of knowledge, only two small sample studies focused on the efficacy of supplementation of CoQ10 on cardiac function.

Associations of coenzyme Q10 with endothelial function in hemodialysis patients.

Background: Endothelial dysfunction is common in patients undergoing hemodialysis (HD). However, little is known about the relationship between endothelial dysfunction and coenzyme Q10 (CoQ10) levels in HD patients.

Methods: Eligible HD patients were enrolled in this study according to prespecified inclusion and exclusion criteria.

Microfluidic Reactors for Plasmonic Photocatalysis Using Gold Nanoparticles.

This work reports a microfluidic reactor that utilizes gold nanoparticles (AuNPs) for the highly efficient photocatalytic degradation of organic pollutants under visible light. The bottom of microchamber has a TiO film covering a layer of AuNPs (namely, TiO/AuNP film) deposited on the F-doped SnO (FTO) substrate. The rough surface of FTO helps to increase the surface area and the AuNPs enables the strong absorption of visible light to excite electron/hole pairs, which are then transferred to the TiO film for photodegradation.

Association of triiodothyronine levels with left ventricular function, cardiovascular events, and mortality in hemodialysis patients.

Background: Hemodialysis (HD) patients have altered free triiodothyronine (fT3) levels. A low fT3 level is a strong and inverse mortality predictor in HD patients. However, little is known about the relationship between fT3 and left ventricular function in HD patients.

Effects of respiration on pulmonary venous flow and its clinical applications by Doppler echocardiography.

Objectives: This study was aimed to explore respiratory variations of pulmonary venous flow and its clinical applications and the potential mechanism.

Methods: Pulsed-wave Doppler waveforms of right-upper pulmonary vein were recorded with Siemens Sequoia 512 in 20 healthy young subjects. Electrocardiogram and respiratory tracing were recorded simultaneously.

The characteristics of the spectra of superior venae cavae in patients with right heart failure.

Background: Aimed to elucidate the characteristics of the spectra of superior venae cavae (SVC) in respiratory cycles in patients with right heart failure.

Methods: The spectra of SVC of 30 patients with right heart failure and 30 paired healthy subjects were recorded through right supraclavicular fossa view. The profiles of spectra of superior venae cavae were observed, and peak velocity and velocity time integral (VTI) of every wave of SVC under spontaneous respiration were measured for statistical analysis.

Immediate and long-term effects of color Doppler ultrasound on myocardial cell apoptosis of fetal rats.

The objective of this article is to evaluate the safety of diagnostic color Doppler ultrasound (CDUS) on embryos by observing its effects on myocardial cell apoptosis of fetal rats. Pregnant Sprague-Dawley rats were divided into fetal group and neonatal group according to the sample-drawing time averagely and randomly, and each group was subdivided into control group and insonification group. The control group was sham-insonificated, and the insonification group was insonificated by diagnostic ultrasound (3.