Impact of 3D Printing Technology-Assisted Rehabilitation Cycles on Prognostic Motility in Surgically Treated Tibial Plateau Fractures: A Meta-Analysis.

Background: Tibial Plateau Fractures (TPF) present significant challenges in orthopedic surgery due to their complex anatomy and associated morbidity. Conventional surgical approaches are often limited by the difficulty in achieving anatomical reduction and stable fixation, leading to prolonged recovery times and increased risk of complications.

Objective: This study aims to evaluate the impact of 3D printing technology-assisted interventions in the surgical management of Tibial Plateau Fractures (TPF).

Two new acetoisovanillone glycosides from the water-soluble fraction of .

The cortex root of , is used as a traditional Chinese medicine for treating female diseases. Phytochemical investigation of the water-soluble fraction of the plant led to the isolation of two new acetoisovanillone glycosides: acetoisovanillone-3D-glucopyranoside () and 2-hydroxy-acetoisovanillone-3---D-glucopyranoside (). Their structures were elucidated by extensive spectroscopic methods.

Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.

A series of pyrido[2,3-d]pyrimidin-5-ones has been synthesized and evaluated as inhibitors of the kinase domain of macrophage colony-stimulating factor-1 receptor (FMS). FMS inhibitors may be useful in treating rheumatoid arthritis and other chronic inflammatory diseases. Structure-based optimization of the lead amide analogue 10 led to hydroxamate analogue 37, which possessed excellent potency and an improved pharmacokinetic profile.

Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors.

A series of pyrimidinopyridones has been designed, synthesized and shown to be potent and selective inhibitors of the FMS tyrosine kinase. Introduction of an amide substituent at the 6-position of the pyridone core resulted in a significant potency increase. Compound 24 effectively inhibited in vivo LPS-induced TNF in mice greater than 80%.

Synthesis of 15-Deoxy-12-hydroxy-10-(trifluoromethyl)-Delta(7)-PGA(1) Methyl Ester.

Cross-conjugated alkylidene prostaglandins have been shown to be potent cytostatic agents that exert their action through a unique and unusual mechanism. Compounds in this class also inhibit viral replication and have a role in osteogenesis and adipogenesis; consequently, they are of considerable current interest as pharmaceutical lead compounds. The purpose of our research was to define an efficent protocol for the assembly of the C-10 trifluoromethyl prostanoid mentioned in the title.