Publications by authors named "Huanxia Liu"
[Analysis of HIV-1 Subtypes and Transmitted Drug Resistance in Hospitalized Treatment-Native Patients With AIDS].
Sichuan Da Xue Xue Bao Yi Xue Ban
September 2024
Article Synopsis
- The study aimed to analyze HIV-1 subtype distribution, transmitted drug resistance (TDR) status, and factors influencing TDR in treatment-naive AIDS patients hospitalized in Chengdu from 2020 to 2022.
- Blood samples were collected from 213 patients, revealing that 83.10% had successfully amplified HIV-1 subtypes, with CRF07_BC (43.50%) and CRF01_AE (37.85%) being the most prevalent.
- Significant differences in subtype distribution were found among different age groups, particularly for CRF01_AE and unique recombinant forms (URFs), with TDR incidences at 6.49% and 8.96% in varying patient demographics
Article Synopsis
- - The study compares the effectiveness and side effects of 400mg and 600mg efavirenz (EFV) in treating HIV-infected patients, concluding that both dosages provide similar antiviral efficacy.
- - A total of 50 patients were divided into two groups receiving either 3TC+TDF+400mg EFV or 3TC+TDF+600mg EFV, with both groups showing HIV inhibition rates of 56.52% at week 24 and nearly full efficacy at week 48.
- - Patients on the 400mg EFV experienced significantly fewer adverse effects, with only 27 reported cases compared to 39 in the 600mg group, particularly reporting lower rates of transamin
Article Synopsis
- - The study evaluated the long-term effects of tenofovir fumarate (TDF) on kidney function in 100 HIV-infected patients who were deemed low-risk for kidney injury, after 3.19 years of treatment with TDF plus other antivirals.
- - Results showed a slight increase in estimated glomerular filtration rate (eGFR) and blood β2 microglobulin levels, with statistically significant changes over time, although the incidence of renal tubular dysfunction remained low.
- - The findings suggest that while long-term TDF can lead to some renal changes, monitoring blood and urine β2 microglobulin levels might be useful for detecting early renal dysfunction, even if changes in these levels did not correlate directly
Treatment options for hospitalized people living with HIV/AIDS (PLWHA) with opportunistic infections and comorbidities are limited in China. Albuvirtide (ABT), a new peptide drug, is a long-acting HIV fusion inhibitor with limited drug-drug interactions and fast onset time. This single-center, retrospective cohort study investigated the effectiveness and safety of ABT plus dolutegravir (DTG) therapy in a real-world setting.
View Article and Find Full Text PDF[Genetic Subtypes and Status of Transmitted Drug Resistance of HIV/AIDS Patients in Sichuan].
Sichuan Da Xue Xue Bao Yi Xue Ban
September 2022
Objective: To investigate the distribution characteristics of the HIV genetic subtypes and the status quo of transmitted drug resistance among HIV/AIDS patients in Sichuan with no previous history of receiving antiretroviral therapy (ART).
Methods: Adult HIV/AIDS patients who were hospitalized in Sichuan and who had no previous history of exposure to ART drugs exposure were enrolled. In-house sequencing of the HIV gene was done and phylogenetic tree was constructed to analyze the HIV genetic subtypes.
Background: The application time of dolutegravir (DTG) is relatively short, and the treatment experience is insufficient. Therefore, evidence is required to shed more light on the effectiveness and safety issues of DTG in China.
Objectives: To assess the effectiveness and safety of a DTG vs.
The synthesized imidazoline phosphate quaternary ammonium salt has low stability, which is spontaneously and rapidly hydrolyzed to the long-chain fatty acid amide (LFA). The hydrolysate (LFA) has been found to be an efficient inhibitor for Q235 steel against CO corrosion, which yields a maximum value above 90% at a concentration of 1000 mg L. The LFA inhibitor acts as an anodic type inhibitor and its inhibition mechanism is a "negative catalysis effect".
View Article and Find Full Text PDFBackground: The regimen containing tenofovir disoproxil fumarate (TDF)+lamivudine or emtricitabine + efavirenz remains the recommended first-line antiretroviral therapy (ART) by the WHO. Limited studies, however, have been conducted on the incidence of renal impairment among Chinese patients with long-term exposure to TDF-containing ART regimens.
Methods: We retrospectively analyzed 269 eligible patients who had no comorbidities and received TDF-containing ART from July 2014 to April 2015.
Smartphone Apps for Pregnant Women: The Gap Between the Quality of Current Apps and Patients' Needs.
Stud Health Technol Inform
October 2018
To explore the gap between women's needs for pregnancy related apps and to evaluate the quality of the top 10 downloaded pregnancy related apps, we designed a cross-sectional study to survey 153 pregnant women. This study showed pregnant women had high requirement against the quality of knowledge content, functions, interface and basic characteristics of apps. The top 10 popular apps showed a range of drawbacks and were far from satisfying the needs of pregnant women.
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